The relation between the omega-3 index and arachidonic acid is bell shaped: Synergistic at low EPA plus DHA status and antagonistic at high EPA plus DHA status

Martine F. Luxwolda; Remko S. Kuipers; Ella N. Smit; Francien V. Velzing-Aarts; D. A. Janneke Dijck-Brouwer; Frits A. J. Muskiet

doi:10.1016/j.plefa.2011.05.004

The relation between the omega-3 index and arachidonic acid is bell shaped: Synergistic at low EPA plus DHA status and antagonistic at high EPA plus DHA status

Martine F. Luxwolda^*, Remko S. Kuipers, Ella N. Smit, Francien V. Velzing-Aarts, D. A. Janneke Dijck-Brouwer, Frits A. J. Muskiet

^*Corresponding author for this work

Faculty of Medical Sciences/UMCG

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

Introduction: The relation between docosahexaenoic (DHA) and eicosapentaenoic (EPA) vs. arachidonic acid (AA) seems characterized by both synergism and antagonism.

Materials and methods: Investigate the relation between EPA + DHA and AA in populations with a wide range of EPA + DHA status and across the life cycle. EPA + DHA and AA were determined in erythrocytes (RBC; n=1979), umbilical arteries (UA; n=789) and umbilical veins (UV; n=785).

Results: In all compartments, notably RBC, the relation between EPA + DHA and AA appeared bell-shaped. Populations with low RBC-EPA + DHA ( 8 g%) negative relationships. Antagonism in UA and UV could not be demonstrated.

Conclusion: Both synergism and antagonism might aim at a balance between omega 6 and omega 3 long-chain polyunsaturated fatty acid (LCP) to maintain homeostasis. Synergism might be a feature of low LCP omega 3 status. AA becomes suppressed by antagonism from an RBC-EPA+DHA > 8 g%. (C) 2011 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	171-178
Number of pages	8
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	85
Issue number	3-4
DOIs	https://doi.org/10.1016/j.plefa.2011.05.004
Publication status	Published - 2011

Keywords

Docosahexaenoic acid DHA
Eicosapentaenoic acid EPA
Arachidonic acid AA
Antagonism
Synergism
Bell-shaped
POLYUNSATURATED FATTY-ACIDS
DIETARY DOCOSAHEXAENOIC ACID
FISH-OIL SUPPLEMENTS
ALPHA-LINOLENIC ACID
EICOSAPENTAENOIC ACID
TERM INFANTS
SERUM-LIPIDS
N-3 PUFA
IN-VIVO
PREGNANCY

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Luxwolda, M. F., Kuipers, R. S., Smit, E. N., Velzing-Aarts, F. V., Dijck-Brouwer, D. A. J., & Muskiet, F. A. J. (2011). The relation between the omega-3 index and arachidonic acid is bell shaped: Synergistic at low EPA plus DHA status and antagonistic at high EPA plus DHA status. Prostaglandins Leukotrienes and Essential Fatty Acids, 85(3-4), 171-178. https://doi.org/10.1016/j.plefa.2011.05.004

@article{a6271e7157f340b8bb9b444e472593fe,

title = "The relation between the omega-3 index and arachidonic acid is bell shaped: Synergistic at low EPA plus DHA status and antagonistic at high EPA plus DHA status",

abstract = "Introduction: The relation between docosahexaenoic (DHA) and eicosapentaenoic (EPA) vs. arachidonic acid (AA) seems characterized by both synergism and antagonism.Materials and methods: Investigate the relation between EPA + DHA and AA in populations with a wide range of EPA + DHA status and across the life cycle. EPA + DHA and AA were determined in erythrocytes (RBC; n=1979), umbilical arteries (UA; n=789) and umbilical veins (UV; n=785).Results: In all compartments, notably RBC, the relation between EPA + DHA and AA appeared bell-shaped. Populations with low RBC-EPA + DHA ( 8 g%) negative relationships. Antagonism in UA and UV could not be demonstrated.Conclusion: Both synergism and antagonism might aim at a balance between omega 6 and omega 3 long-chain polyunsaturated fatty acid (LCP) to maintain homeostasis. Synergism might be a feature of low LCP omega 3 status. AA becomes suppressed by antagonism from an RBC-EPA+DHA > 8 g%. (C) 2011 Elsevier Ltd. All rights reserved.",

keywords = "Docosahexaenoic acid DHA, Eicosapentaenoic acid EPA, Arachidonic acid AA, Antagonism, Synergism, Bell-shaped, POLYUNSATURATED FATTY-ACIDS, DIETARY DOCOSAHEXAENOIC ACID, FISH-OIL SUPPLEMENTS, ALPHA-LINOLENIC ACID, EICOSAPENTAENOIC ACID, TERM INFANTS, SERUM-LIPIDS, N-3 PUFA, IN-VIVO, PREGNANCY",

author = "Luxwolda, {Martine F.} and Kuipers, {Remko S.} and Smit, {Ella N.} and Velzing-Aarts, {Francien V.} and Dijck-Brouwer, {D. A. Janneke} and Muskiet, {Frits A. J.}",

year = "2011",

doi = "10.1016/j.plefa.2011.05.004",

language = "English",

volume = "85",

pages = "171--178",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

issn = "0952-3278",

publisher = "ELSEVIER SCI LTD",

number = "3-4",

}

Luxwolda, MF, Kuipers, RS, Smit, EN, Velzing-Aarts, FV, Dijck-Brouwer, DAJ & Muskiet, FAJ 2011, 'The relation between the omega-3 index and arachidonic acid is bell shaped: Synergistic at low EPA plus DHA status and antagonistic at high EPA plus DHA status', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 85, no. 3-4, pp. 171-178. https://doi.org/10.1016/j.plefa.2011.05.004

The relation between the omega-3 index and arachidonic acid is bell shaped: Synergistic at low EPA plus DHA status and antagonistic at high EPA plus DHA status. / Luxwolda, Martine F.; Kuipers, Remko S.; Smit, Ella N. et al.
In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 85, No. 3-4, 2011, p. 171-178.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The relation between the omega-3 index and arachidonic acid is bell shaped

T2 - Synergistic at low EPA plus DHA status and antagonistic at high EPA plus DHA status

AU - Luxwolda, Martine F.

AU - Kuipers, Remko S.

AU - Smit, Ella N.

AU - Velzing-Aarts, Francien V.

AU - Dijck-Brouwer, D. A. Janneke

AU - Muskiet, Frits A. J.

PY - 2011

Y1 - 2011

N2 - Introduction: The relation between docosahexaenoic (DHA) and eicosapentaenoic (EPA) vs. arachidonic acid (AA) seems characterized by both synergism and antagonism.Materials and methods: Investigate the relation between EPA + DHA and AA in populations with a wide range of EPA + DHA status and across the life cycle. EPA + DHA and AA were determined in erythrocytes (RBC; n=1979), umbilical arteries (UA; n=789) and umbilical veins (UV; n=785).Results: In all compartments, notably RBC, the relation between EPA + DHA and AA appeared bell-shaped. Populations with low RBC-EPA + DHA ( 8 g%) negative relationships. Antagonism in UA and UV could not be demonstrated.Conclusion: Both synergism and antagonism might aim at a balance between omega 6 and omega 3 long-chain polyunsaturated fatty acid (LCP) to maintain homeostasis. Synergism might be a feature of low LCP omega 3 status. AA becomes suppressed by antagonism from an RBC-EPA+DHA > 8 g%. (C) 2011 Elsevier Ltd. All rights reserved.

AB - Introduction: The relation between docosahexaenoic (DHA) and eicosapentaenoic (EPA) vs. arachidonic acid (AA) seems characterized by both synergism and antagonism.Materials and methods: Investigate the relation between EPA + DHA and AA in populations with a wide range of EPA + DHA status and across the life cycle. EPA + DHA and AA were determined in erythrocytes (RBC; n=1979), umbilical arteries (UA; n=789) and umbilical veins (UV; n=785).Results: In all compartments, notably RBC, the relation between EPA + DHA and AA appeared bell-shaped. Populations with low RBC-EPA + DHA ( 8 g%) negative relationships. Antagonism in UA and UV could not be demonstrated.Conclusion: Both synergism and antagonism might aim at a balance between omega 6 and omega 3 long-chain polyunsaturated fatty acid (LCP) to maintain homeostasis. Synergism might be a feature of low LCP omega 3 status. AA becomes suppressed by antagonism from an RBC-EPA+DHA > 8 g%. (C) 2011 Elsevier Ltd. All rights reserved.

KW - Docosahexaenoic acid DHA

KW - Eicosapentaenoic acid EPA

KW - Arachidonic acid AA

KW - Antagonism

KW - Synergism

KW - Bell-shaped

KW - POLYUNSATURATED FATTY-ACIDS

KW - DIETARY DOCOSAHEXAENOIC ACID

KW - FISH-OIL SUPPLEMENTS

KW - ALPHA-LINOLENIC ACID

KW - EICOSAPENTAENOIC ACID

KW - TERM INFANTS

KW - SERUM-LIPIDS

KW - N-3 PUFA

KW - IN-VIVO

KW - PREGNANCY

U2 - 10.1016/j.plefa.2011.05.004

DO - 10.1016/j.plefa.2011.05.004

M3 - Article

SN - 0952-3278

VL - 85

SP - 171

EP - 178

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 3-4

ER -

The relation between the omega-3 index and arachidonic acid is bell shaped: Synergistic at low EPA plus DHA status and antagonistic at high EPA plus DHA status

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