The renal angiopoietin/Tie2 system in lethal human sepsis

Adnan Aslan; Rianne M. Jongman; Jill Moser; Coen A. Stegeman; Harry van Goor; Arjan Diepstra; Marius C. van den Heuvel; Peter Heeringa; Grietje Molema; Jan G. Zijlstra; Matijs van Meurs

doi:10.1186/cc13806

The renal angiopoietin/Tie2 system in lethal human sepsis

Adnan Aslan, Rianne M. Jongman, Jill Moser, Coen A. Stegeman, Harry van Goor, Arjan Diepstra, Marius C. van den Heuvel, Peter Heeringa, Grietje Molema, Jan G. Zijlstra^*, Matijs van Meurs

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Academic › peer-review

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Abstract

Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking.. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed in such a way that microvessels become destabilized.

Original language	English
Article number	423
Number of pages	3
Journal	Critical care (London, England)
Volume	18
Issue number	2
DOIs	https://doi.org/10.1186/cc13806
Publication status	Published - 31-Mar-2014

Keywords

SHOCK
TIE2

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The renal angiopoietin/Tie2 system in lethal human sepsisFinal publisher's version, 288 KBLicence: CC BY

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@article{537244a192d94a7684f1656885de5c6e,

title = "The renal angiopoietin/Tie2 system in lethal human sepsis",

abstract = "Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking.. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed in such a way that microvessels become destabilized.",

keywords = "SHOCK, TIE2",

author = "Adnan Aslan and Jongman, {Rianne M.} and Jill Moser and Stegeman, {Coen A.} and {van Goor}, Harry and Arjan Diepstra and {van den Heuvel}, {Marius C.} and Peter Heeringa and Grietje Molema and Zijlstra, {Jan G.} and {van Meurs}, Matijs",

year = "2014",

month = mar,

day = "31",

doi = "10.1186/cc13806",

language = "English",

volume = "18",

journal = "Critical care (London, England)",

issn = "1466-609X",

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TY - JOUR

T1 - The renal angiopoietin/Tie2 system in lethal human sepsis

AU - Aslan, Adnan

AU - Jongman, Rianne M.

AU - Moser, Jill

AU - Stegeman, Coen A.

AU - van Goor, Harry

AU - Diepstra, Arjan

AU - van den Heuvel, Marius C.

AU - Heeringa, Peter

AU - Molema, Grietje

AU - Zijlstra, Jan G.

AU - van Meurs, Matijs

PY - 2014/3/31

Y1 - 2014/3/31

N2 - Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking.. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed in such a way that microvessels become destabilized.

AB - Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking.. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed in such a way that microvessels become destabilized.

KW - SHOCK

KW - TIE2

U2 - 10.1186/cc13806

DO - 10.1186/cc13806

M3 - Letter

C2 - 24976393

SN - 1466-609X

VL - 18

JO - Critical care (London, England)

JF - Critical care (London, England)

IS - 2

M1 - 423

ER -

The renal angiopoietin/Tie2 system in lethal human sepsis

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