The renin-angiotensin system and vascular function. The role of angiotensin II, angiotensin-converting enzyme, and alternative conversion of angiotensin I

A Roks*, H Buikema, YM Pinto, WH van Gilst

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

The renin-angiotensin system has been implicated in vascular function and disease. Angiotensin-converting enzyme and angiotensin II are believed to be the most important components. However, alternative factors, such as angiotensin-I/II-(1-7) and chymase, have also been shown to be of significance in animal models. In this paper, we review some facts and provide additional proof for the functional significance of angiotensin-I/II-(1-7) and chymase in humans.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalHeart and vessels
Publication statusPublished - 1997
EventInternational Session of the 61st Annual Scientific Meeting of the Japanese-Circulation-Society (Circulation 97) - , Japan
Duration: 31-Mar-19972-Apr-1997

Keywords

  • ACE inhibition
  • Ang-(1-7)
  • chymase
  • vascular function
  • CORONARY-ARTERY DISEASE
  • SPONTANEOUSLY HYPERTENSIVE RATS
  • ENDOTHELIAL FUNCTION
  • BLOOD-PRESSURE
  • NITRIC-OXIDE
  • NEOINTIMA FORMATION
  • RELAXING FACTOR
  • HEART-FAILURE
  • GENE-TRANSFER
  • INHIBITION

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