The role of clock genes in sleep, stress and memory

Youri G. Bolsius, Matias D. Zurbriggen, Jae Kyoung Kim, Martien J. Kas, Peter Meerlo, Sara J. Aton*, Robbert Havekes*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Circadian clock genes serve as the molecular basis for animals' ∼24-h internal timekeeping. Clock gene expression inside and outside of the mammalian brain's circadian pacemaker (i.e. the SCN) integrates temporal information into a wealth of physiological processes. Ample data suggests that in addition to canonical cellular timekeeping functions, clock proteins also interact with proteins involved in cellular processes not related to timekeeping, including protein regulation and the interaction with other signaling mechanisms not directly linked to the regulation of circadian rhythms. Indeed, recent data suggests that clock genes outside the SCN are involved in fundamental brain processes such as sleep/wakefulness, stress and memory. The role of clock genes in these brain processes are complex and divers, influencing many molecular pathways and phenotypes. In this review, we will discuss recent work on the involvement of clock genes in sleep, stress, and memory. Moreover, we raise the controversial possibility that these functions may be under certain circumstances independent of their circadian timekeeping function.

Original languageEnglish
Article number114493
JournalBiochemical Pharmacology
Early online date27-Feb-2021
Publication statusPublished - Sep-2021

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