The role of diabetes mellitus in the effectiveness of intradialytic exercise intervention on patients' muscle function

Viera Kissova, Aurel Zelko, Jaroslav Rosenberger, Andrea Madarasova Geckova*

*Corresponding author for this work

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    Introduction: The purpose of this study is to identify the role of diabetes mellitus in the effectiveness of intradialytic exercise intervention among haemodialysis patients.

    Methods: In this multicentre study 90 dialysed patients were allocated to the experimental (EXG, n = 57) or control group (CNG, n = 33). In EXG, we included 20 diabetic and 37 non-diabetic patients. In CNG, we enrolled 8 diabetic and 25 non-diabetic patients. EXG underwent a 12-week supervised, progressive, intradialytic resistance training programme, while CNG stayed inactive during dialysis. Baseline, post-interventional and post-follow-up assessments of maximal force during hip extension (HE), hip flexion (HF) and knee extension (KE) contractions were completed in both groups of patients.

    Results: HE increased in diabetic and non-diabetic EXG patients (diabetic EXG, change: +14.5 N; 95% CI = -5.5 to +34.5; non-diabetic EXG, +18.6 N; 95% CI = +3.4 to +33.8) and diabetic CNG patients (change: +17.9 N; 95% CI = -9.2 to +44.9). Only non-diabetic CNG patients experienced a decrease in HE (change: -22.8 N; 95% CI = -36.9 to -8.7, P < .05).

    Conclusions: Resistance training improved muscle function among dialysis patients regardless of the presence of diabetes mellitus. We found that non-diabetic patients lose their muscle function extensively during inactivity, while diabetic patients retain their muscle function. (c) 2021 The Author(s). Published by Elsevier Espana, S.L.U. on behalf of SEEN y SED. This is an open access article under the CC BY-NC-ND license (

    Original languageEnglish
    Pages (from-to)112-121
    Number of pages10
    JournalEndocrinologia diabetes y nutricion
    Issue number2
    Publication statusPublished - Feb-2022


    • Diabetes mellitus
    • Chronic kidney disease
    • Haemodialysis
    • Intradialytic exercise
    • Muscle function

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