The Role of Gasotransmitters in Gut Peptide Actions

Wout Verbeure; Harry van Goor; Hideki Mori; André P van Beek; Jan Tack; Peter R van Dijk

doi:10.3389/fphar.2021.720703

The Role of Gasotransmitters in Gut Peptide Actions

Wout Verbeure, Harry van Goor, Hideki Mori, André P van Beek, Jan Tack^*, Peter R van Dijk

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) receive a bad connotation; in low concentrations these play a major governing role in local and systemic blood flow, stomach acid release, smooth muscles relaxations, anti-inflammatory behavior, protective effect and more. Many of these physiological processes are upstream regulated by gut peptides, for instance gastrin, cholecystokinin, secretin, motilin, ghrelin, glucagon-like peptide 1 and 2. The relationship between gasotransmitters and gut hormones is poorly understood. In this review, we discuss the role of NO, CO and H2S on gut peptide release and functioning, and whether manipulation by gasotransmitter substrates or specific blockers leads to physiological alterations.

Original language	English
Article number	720703
Number of pages	22
Journal	Frontiers in Pharmacology
Volume	12
DOIs	https://doi.org/10.3389/fphar.2021.720703
Publication status	Published - Jul-2021

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title = "The Role of Gasotransmitters in Gut Peptide Actions",

abstract = "Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) receive a bad connotation; in low concentrations these play a major governing role in local and systemic blood flow, stomach acid release, smooth muscles relaxations, anti-inflammatory behavior, protective effect and more. Many of these physiological processes are upstream regulated by gut peptides, for instance gastrin, cholecystokinin, secretin, motilin, ghrelin, glucagon-like peptide 1 and 2. The relationship between gasotransmitters and gut hormones is poorly understood. In this review, we discuss the role of NO, CO and H2S on gut peptide release and functioning, and whether manipulation by gasotransmitter substrates or specific blockers leads to physiological alterations.",

author = "Wout Verbeure and {van Goor}, Harry and Hideki Mori and {van Beek}, {Andr{\'e} P} and Jan Tack and {van Dijk}, {Peter R}",

note = "Copyright {\textcopyright} 2021 Verbeure, van Goor, Mori, van Beek, Tack and van Dijk.",

year = "2021",

month = jul,

doi = "10.3389/fphar.2021.720703",

language = "English",

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journal = "Frontiers in Pharmacology",

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AU - Verbeure, Wout

AU - van Goor, Harry

AU - Mori, Hideki

AU - van Beek, André P

AU - Tack, Jan

AU - van Dijk, Peter R

PY - 2021/7

Y1 - 2021/7

N2 - Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) receive a bad connotation; in low concentrations these play a major governing role in local and systemic blood flow, stomach acid release, smooth muscles relaxations, anti-inflammatory behavior, protective effect and more. Many of these physiological processes are upstream regulated by gut peptides, for instance gastrin, cholecystokinin, secretin, motilin, ghrelin, glucagon-like peptide 1 and 2. The relationship between gasotransmitters and gut hormones is poorly understood. In this review, we discuss the role of NO, CO and H2S on gut peptide release and functioning, and whether manipulation by gasotransmitter substrates or specific blockers leads to physiological alterations.

AB - Although gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) receive a bad connotation; in low concentrations these play a major governing role in local and systemic blood flow, stomach acid release, smooth muscles relaxations, anti-inflammatory behavior, protective effect and more. Many of these physiological processes are upstream regulated by gut peptides, for instance gastrin, cholecystokinin, secretin, motilin, ghrelin, glucagon-like peptide 1 and 2. The relationship between gasotransmitters and gut hormones is poorly understood. In this review, we discuss the role of NO, CO and H2S on gut peptide release and functioning, and whether manipulation by gasotransmitter substrates or specific blockers leads to physiological alterations.

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DO - 10.3389/fphar.2021.720703

M3 - Review article

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SN - 1663-9812

VL - 12

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

M1 - 720703

ER -

The Role of Gasotransmitters in Gut Peptide Actions

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