The role of MIF in chronic lung diseases: Looking beyond inflammation

Laura Florez-Sampedro, Abel Soto-Gamez, Gerrit J Poelarends, Barbro N Melgert*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
64 Downloads (Pure)

Abstract

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been associated with many diseases. Most studies found in literature describe MIF as a proinflammatory cytokine involved in chronic inflammatory conditions, but evidence from last years suggests that many of its key effects are not directly related to inflammation. In fact, MIF is constitutively expressed in most human tissues and in some cases in high levels, which does not reflect the pattern of expression of a classic proinflammatory cytokine. Moreover, MIF is highly expressed during embryonic development and decreases during adulthood, which point toward a more likely role as growth factor. Accordingly, MIF knockout mice develop age-related spontaneous emphysema, suggesting that MIF presence (e.g., in younger individuals and wild-type animals) is part of a healthy lung. In view of this new line of evidence, we aimed to review data on the role of MIF in the pathogenesis of chronic lung diseases.

Original languageEnglish
Pages (from-to) L1183-L1197
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume318
Issue number6
Early online date25-Mar-2020
DOIs
Publication statusPublished - Jun-2020

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