Regarding late morbidity, hyposalivation is one of the most frequently reported radiation-induced side effects which has a negative impact on health-related quality of life [1;2]. Besides the subjective sensation of a dry mouth (xerostomia), saliva also plays a major role in speech, taste perception, mastication, bolus formation, swallowing, rinsing the mouth, clearing and diluting food detritus and bacterial matter, and mucosal protection [3;4]. In this thesis we investigated the role and the mechanisms of pilocarpine treatment during radiotherapy in the prevention and reduction of radiation-induced hyposalivation.
|Qualification||Doctor of Philosophy|
|Publication status||Published - 2008|
- Proefschriften (vorm)
- Pilocarpine , Stralingsbeschadiging, Speekselklieren , Bestr
- Xerostomie , Tumoren, Speeksel,
- neoplasmata, gezwellen