The role of pilocarpine in the reduction of radiation induced damage to the salivary glands

Fred Ronald Burlage

Research output: ThesisThesis fully internal (DIV)

101 Downloads (Pure)


Regarding late morbidity, hyposalivation is one of the most frequently reported radiation-induced side effects which has a negative impact on health-related quality of life [1;2]. Besides the subjective sensation of a dry mouth (xerostomia), saliva also plays a major role in speech, taste perception, mastication, bolus formation, swallowing, rinsing the mouth, clearing and diluting food detritus and bacterial matter, and mucosal protection [3;4]. In this thesis we investigated the role and the mechanisms of pilocarpine treatment during radiotherapy in the prevention and reduction of radiation-induced hyposalivation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Groningen
  • Langendijk, Johannes Albertus, Supervisor
  • Vissink, Arjan, Supervisor
  • Kampinga, Harrie, Supervisor
Award date11-Jun-2008
Print ISBNs9789036733809
Publication statusPublished - 2008


  • Proefschriften (vorm)
  • Pilocarpine , Stralingsbeschadiging, Speekselklieren , Bestr
  • Xerostomie , Tumoren, Speeksel,
  • neoplasmata, gezwellen
  • radiologie

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