The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits

Melinda C. Mills*, Nicola Barban, Felix C. Tropf

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
36 Downloads (Pure)

Abstract

Human reproductive behavior until relatively recently has been explained exclusively via individual and social characteristics. This article applies results from a recent Genome-Wide Association Study that combined sixty-two data sources to isolate twelve genetic loci associated with reproductive behavior. We create polygenic scores that allow us to include a summary variable of genetic factors into our statistical models. We use four datasets: the U.S. Health and Retirement Study, Dutch LifeLines, TwinsUK and the Swedish Twin register. First, we provide a brief overview of the dominant explanations of reproductive behavior. Second, we test the predictive power of polygenic scores. Third, we interrogate the robustness of our models using a series of sensitivity analyses to take into account possible confounders due to population stratification and selection.

Original languageEnglish
Pages (from-to)122-136
Number of pages15
JournalRSF
Volume4
Issue number4
DOIs
Publication statusPublished - 1-Apr-2018
Externally publishedYes

Keywords

  • Age at first birth
  • Educational attainment
  • Fertility
  • Genetics
  • Human reproduction
  • Number of children ever born
  • Polygenic scores

Fingerprint

Dive into the research topics of 'The sociogenomics of polygenic scores of reproductive behavior and their relationship to other fertility traits'. Together they form a unique fingerprint.

Cite this