The term CAKUT has outlived its usefulness: the case for the defense

Nine V. A. M. Knoers

doi:10.1007/s00467-022-05678-z

The term CAKUT has outlived its usefulness: the case for the defense

Nine V. A. M. Knoers^*

^*Corresponding author for this work

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Abstract

Congenital anomalies of the kidney and urinary tract form a spectrum of congenital structural disorders that are generally known under the term CAKUT. The term CAKUT was introduced 20 years ago and has been used extensively in literature since. Prof. Woolf has made a plea for abandoning this term in his "case for the prosecution." Here, I advocate for the continued use of CAKUT as an umbrella term for these related congenital kidney and urinary tract abnormalities. I explain why the term CAKUT accurately and usefully defines this group of related structural disorders with prenatal origin and why it makes sense to continue grouping these disorders given accumulating evidence for shared etiology of CAKUT phenotypes and the importance of grouping CAKUT phenotypes in genetic counseling.

Original language	English
Pages (from-to)	2793–2798
Number of pages	6
Journal	Pediatric Nephrology
Volume	37
Early online date	22-Jul-2022
DOIs	https://doi.org/10.1007/s00467-022-05678-z
Publication status	Published - Nov-2022

Keywords

CAKUT
Chronic kidney disease
Shared etiology
Variable expressivity
Reduced penetrance
Genetic counseling
URINARY-TRACT MALFORMATIONS
CONGENITAL-ANOMALIES
MONOZYGOTIC TWINS
KIDNEY
DISCORDANT
AGENESIS

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title = "The term CAKUT has outlived its usefulness: the case for the defense",

abstract = "Congenital anomalies of the kidney and urinary tract form a spectrum of congenital structural disorders that are generally known under the term CAKUT. The term CAKUT was introduced 20 years ago and has been used extensively in literature since. Prof. Woolf has made a plea for abandoning this term in his {"}case for the prosecution.{"} Here, I advocate for the continued use of CAKUT as an umbrella term for these related congenital kidney and urinary tract abnormalities. I explain why the term CAKUT accurately and usefully defines this group of related structural disorders with prenatal origin and why it makes sense to continue grouping these disorders given accumulating evidence for shared etiology of CAKUT phenotypes and the importance of grouping CAKUT phenotypes in genetic counseling.",

keywords = "CAKUT, Chronic kidney disease, Shared etiology, Variable expressivity, Reduced penetrance, Genetic counseling, URINARY-TRACT MALFORMATIONS, CONGENITAL-ANOMALIES, MONOZYGOTIC TWINS, KIDNEY, DISCORDANT, AGENESIS",

author = "Knoers, {Nine V. A. M.}",

year = "2022",

month = nov,

doi = "10.1007/s00467-022-05678-z",

language = "English",

volume = "37",

pages = "2793–2798",

journal = "Pediatric Nephrology",

issn = "0931-041X",

publisher = "Springer",

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TY - JOUR

T1 - The term CAKUT has outlived its usefulness

T2 - the case for the defense

AU - Knoers, Nine V. A. M.

PY - 2022/11

Y1 - 2022/11

N2 - Congenital anomalies of the kidney and urinary tract form a spectrum of congenital structural disorders that are generally known under the term CAKUT. The term CAKUT was introduced 20 years ago and has been used extensively in literature since. Prof. Woolf has made a plea for abandoning this term in his "case for the prosecution." Here, I advocate for the continued use of CAKUT as an umbrella term for these related congenital kidney and urinary tract abnormalities. I explain why the term CAKUT accurately and usefully defines this group of related structural disorders with prenatal origin and why it makes sense to continue grouping these disorders given accumulating evidence for shared etiology of CAKUT phenotypes and the importance of grouping CAKUT phenotypes in genetic counseling.

AB - Congenital anomalies of the kidney and urinary tract form a spectrum of congenital structural disorders that are generally known under the term CAKUT. The term CAKUT was introduced 20 years ago and has been used extensively in literature since. Prof. Woolf has made a plea for abandoning this term in his "case for the prosecution." Here, I advocate for the continued use of CAKUT as an umbrella term for these related congenital kidney and urinary tract abnormalities. I explain why the term CAKUT accurately and usefully defines this group of related structural disorders with prenatal origin and why it makes sense to continue grouping these disorders given accumulating evidence for shared etiology of CAKUT phenotypes and the importance of grouping CAKUT phenotypes in genetic counseling.

KW - CAKUT

KW - Chronic kidney disease

KW - Shared etiology

KW - Variable expressivity

KW - Reduced penetrance

KW - Genetic counseling

KW - URINARY-TRACT MALFORMATIONS

KW - CONGENITAL-ANOMALIES

KW - MONOZYGOTIC TWINS

KW - KIDNEY

KW - DISCORDANT

KW - AGENESIS

U2 - 10.1007/s00467-022-05678-z

DO - 10.1007/s00467-022-05678-z

M3 - Article

SN - 0931-041X

VL - 37

SP - 2793

EP - 2798

JO - Pediatric Nephrology

JF - Pediatric Nephrology

ER -

The term CAKUT has outlived its usefulness: the case for the defense

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