The thyromimetic T-0681 protects from atherosclerosis

Ivan Tancevski*, Andreas Wehinger, Egon Demetz, Julia Hoefer, Philipp Eller, Eva Huber, Ursula Stanzl, Kristina Duwensee, Kristina Auer, Wilfried Schgoer, Volker Kuhn, Catherine Fievet, Frans Stellaard, Mats Rudling, Bernhard Foeger, Josef R. Patsch, Andreas Ritsch

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    29 Citations (Scopus)

    Abstract

    This report describes studies in hyperlipidemic New Zealand White (NZW) rabbits investigating the impact of the liver-selective thyromimetic T-0681 on lipoprotein metabolism and the development of atherosclerosis. Prolonged treatment with T-0681 increased the hepatic expression of both LDL receptor and scavenger receptor class B, type I without affecting cholesteryl ester transfer protein activity. Upregulation of hepatic lipoprotein receptors was accompanied by a marked decrease of apolipoprotein B-containing lipoproteins, reflected by a 60% reduction of plasma cholesterol and a > 70% reduction of plasma triglyceride levels. Most importantly, T-0681 reduced the development of atherosclerosis by 80% in NZW rabbits on high-cholesterol chow. jlr Our data suggest that liver-selective thyromimetics, such as T-0681, may prove to be useful therapeutic agents against the development of atherosclerosis in humans.-Tancevski, I., A. Wehinger, E. Demetz, J. Hoefer, P. Eller, E. Huber, U. Stanzl, K. Duwensee, K. Auer, W. Schgoer, V. Kuhn, C. Fievet, F. Stellaard, M. Rudling, B. Foeger, J. R. Patsch, and A. Ritsch. The thyromimetic T-0681 protects from atherosclerosis. J. Lipid Res. 2009. 50: 938-944.

    Original languageEnglish
    Pages (from-to)938-944
    Number of pages7
    JournalJournal of Lipid Research
    Volume50
    Issue number5
    DOIs
    Publication statusPublished - May-2009

    Keywords

    • liver-selective thyromimetic
    • low density lipoprotein receptor
    • scavenger receptor class B, type I
    • potential side effects
    • DENSITY-LIPOPROTEIN RECEPTOR
    • REVERSE CHOLESTEROL TRANSPORT
    • ESTER TRANSFER PROTEIN
    • B TYPE-I
    • LDL CHOLESTEROL
    • MICE
    • EXPRESSION
    • APOLIPOPROTEIN
    • LIVER
    • HYPOTHYROIDISM

    Cite this