The treatment and survival of elderly patients with locally advanced pancreatic cancer: A post-hoc analysis of a multicenter registry

Dutch Pancreatic Canc Grp, L. J. H. Brada, M. S. Walma, R. M. van Dam, J. de Vos-Geelen, I. H. de Hingh, G. J. Creemers, M. S. Liem, L. J. Mekenkamp, V. E. de Meijer, D. J. A. de Groot, G. A. Patijn, J. W. B. de Groot, S. Festen, E. D. Kerver, M. W. J. Stommel, M. R. Meijerink, K. Bosscha, J. F. Pruijt, M. B. PoleeJ. A. Ropela, G. A. Cirkel, M. Los, J. W. Wilmink, N. Haj Mohammad, H. C. van Santvoort, M. G. Besselink, I. Q. Molenaar

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Abstract

Background: The treatment options for patients with locally advanced pancreatic cancer (LAPC) have improved in recent years and consequently survival has increased. It is unknown, however, if elderly patients benefit from these improvements in therapy. With the ongoing aging of the patient population and an increasing incidence of pancreatic cancer, this patient group becomes more relevant. This study aims to clarify the association between increasing age, treatment and overall survival in patients with LAPC.

Methods: Post-hoc analysis of a multicenter registry including consecutive patients with LAPC, who were registered in 14 centers of the Dutch Pancreatic Cancer Group (April 2015-December 2017). Patients were divided in three groups according to age (= 75 years). Primary outcome was overall survival stratified by primary treatment strategy. Multivariable regression analyses were performed to adjust for possible confounders.

Results: Overall, 422 patients with LAPC were included; 162 patients (38%) aged = 75 years. Chemotherapy was administered in 86%, 81% and 50% of the patients in the different age groups (p

Conclusion: Elderly patients are less likely to be treated with chemotherapy, but when treated with chemotherapy, their survival is comparable to younger patients. (C) 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalPancreatology
Volume21
Issue number1
DOIs
Publication statusPublished - Jan-2021

Keywords

  • Locally advanced pancreatic cancer
  • Chemotherapy
  • Elderly
  • Best supportive care
  • NAB-PACLITAXEL
  • OLDER PATIENTS
  • AGE
  • GEMCITABINE
  • FOLFIRINOX
  • ADENOCARCINOMA
  • CHEMOTHERAPY
  • COMORBIDITY
  • DISPARITIES
  • OUTCOMES

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