The Twin Interdisciplinary Neuroticism Study

Harriette Riese; Fruehling V. Rijsdijk; Harold Snieder; Johan Ormel

doi:10.1017/thg.2012.112

The Twin Interdisciplinary Neuroticism Study

Harriette Riese^*, Fruehling V. Rijsdijk, Harold Snieder, Johan Ormel

^*Corresponding author for this work

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Abstract

The Twin Interdisciplinary Neuroticism Study (TWINS) is a three-wave study including >800 twin pairs from the northern part of the Netherlands. The aim of the study is to unravel why neuroticism reflects vulnerability to mental disorders. In this study, we focus on possible mechanisms underlying this vulnerability and their genetic and environmental origins. In total, 125 female twin pairs visited our psychophysiological laboratory. From these twin pairs DNA was isolated and both candidate gene and genome-wide genotyping were conducted. Future work includes studies of candidate genes. The study also participates in several metagenome-wide association study (GWAS) consortia.

Original language	English
Pages (from-to)	268-270
Number of pages	3
Journal	Twin research and human genetics
Volume	16
Issue number	1
DOIs	https://doi.org/10.1017/thg.2012.112
Publication status	Published - Feb-2013

Keywords

neuroticism
DNA
psychophysiology
cardiac autonomic nervous system
HPA-axis
cognitive bias
GENETIC INFLUENCES
SENSITIVITY

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title = "The Twin Interdisciplinary Neuroticism Study",

abstract = "The Twin Interdisciplinary Neuroticism Study (TWINS) is a three-wave study including >800 twin pairs from the northern part of the Netherlands. The aim of the study is to unravel why neuroticism reflects vulnerability to mental disorders. In this study, we focus on possible mechanisms underlying this vulnerability and their genetic and environmental origins. In total, 125 female twin pairs visited our psychophysiological laboratory. From these twin pairs DNA was isolated and both candidate gene and genome-wide genotyping were conducted. Future work includes studies of candidate genes. The study also participates in several metagenome-wide association study (GWAS) consortia.",

keywords = "neuroticism, DNA, psychophysiology, cardiac autonomic nervous system, HPA-axis, cognitive bias, GENETIC INFLUENCES, SENSITIVITY",

author = "Harriette Riese and Rijsdijk, {Fruehling V.} and Harold Snieder and Johan Ormel",

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AU - Snieder, Harold

AU - Ormel, Johan

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KW - neuroticism

KW - DNA

KW - psychophysiology

KW - cardiac autonomic nervous system

KW - HPA-axis

KW - cognitive bias

KW - GENETIC INFLUENCES

KW - SENSITIVITY

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VL - 16

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JO - Twin research and human genetics

JF - Twin research and human genetics

IS - 1

ER -

The Twin Interdisciplinary Neuroticism Study

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