Abstract
Large drug trials have become very important to determine which drugs should be used in the treatment of patients with chronic heart failure (CHF). When these trials showed "positive" results, publication of the data soon followed, leading to a substantial impact on prescription patterns. In the case of "negative" results, many times they were not published, or were reported as an abstract or as short paper disclosing only the main findings. In this article we will discuss some of these trials that were conducted in the last 10 years, since we believe they may provide insight into the pathophysiology and treatment options in CHF. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 19-27 |
| Number of pages | 9 |
| Journal | International Journal of Cardiology |
| Volume | 80 |
| Issue number | 1 |
| Publication status | Published - Aug-2001 |
Keywords
- chronic heart failure
- drug trials
- LEFT-VENTRICULAR DYSFUNCTION
- ENDOTHELIN-RECEPTOR ANTAGONIST
- MYOCARDIAL-INFARCTION
- PLASMA NOREPINEPHRINE
- RANDOMIZED TRIAL
- MORTALITY
- SURVIVAL
- MIBEFRADIL
- MORBIDITY
- FLOSEQUINAN