The Unruptured Intracranial Aneurysm Treatment Score as a Predictor of Aneurysm Growth or Rupture

Rob Molenberg*, Marlien W Aalbers, Aryan Mazuri, Gert Jan Luijckx, Jan D M Metzemaekers, Rob J M Groen, Maarten Uyttenboogaart, J Marc C van Dijk

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background and purpose: The Unruptured Intracranial Aneurysm Treatment Score (UIATS) was built to harmonize the treatment decision making on unruptured intracranial aneurysms. Therefore, it may also function as a predictor of aneurysm progression. In this study, we aimed to assess the validity of the UIATS model to identify aneurysms at risk of growth or rupture during follow-up.

Methods: We calculated the UIATS for a consecutive series of conservatively treated unruptured intracranial aneurysms, included in our prospectively kept neurovascular database. Computed tomography angiography and/or magnetic resonance angiography imaging at baseline and during follow-up was analyzed to detect aneurysm growth. We defined rupture as a cerebrospinal fluid or computed tomography-proven subarachnoid hemorrhage. We calculated the area under the receiver operator curve, sensitivity, and specificity, to determine the performance of the UIATS model.

Results: We included 214 consecutive patients with 277 unruptured intracranial aneurysms. Aneurysms were followed for a median period of 1.3 years (range 0.3-11.7 years). During follow-up, 17 aneurysms enlarged (6.1%), and two aneurysms ruptured (0.7%). The UIATS model showed a sensitivity of 80% and a specificity of 44%. The area under the receiver operator curve was 0.62 (95% confidence interval 0.46-0.79).

Conclusions: Our observational study involving consecutive patients with an unruptured intracranial aneurysm showed poor performance of the UIATS model to predict aneurysm growth or rupture during follow-up.

Original languageEnglish
Pages (from-to)837-843
Number of pages7
JournalEuropean Journal of Neurology
Issue number3
Early online date11-Nov-2020
Publication statusPublished - Mar-2021


  • growth
  • intracranial aneurysm
  • predictors
  • subarachnoid hemorrhage
  • RISK
  • SEX
  • AGE

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