The use of autologous platelet-leukocyte gels to enhance the healing process in surgery, a review

P. A. Everts; E. P. Overdevest; J. J. Jakimowicz; C. J. Oosterbos; J. P. Schonberger; J. T. Knape; A. van Zundert

doi:10.1007/s00464-007-9293-x

The use of autologous platelet-leukocyte gels to enhance the healing process in surgery, a review

P. A. Everts^*, E. P. Overdevest, J. J. Jakimowicz, C. J. Oosterbos, J. P. Schonberger, J. T. Knape, A. van Zundert

^*Corresponding author for this work

University of Groningen

Research output: Contribution to journal › Article › Academic › peer-review

79 Citations (Scopus)

Abstract

Background: The therapeutic use of autologously prepared, platelet-leukocyte-enriched gel (PLG) is a relatively new technology for the stimulation and acceleration of soft tissue and bone healing. The effectiveness of this procedure lies in the delivery of a wide range of platelet growth factors mimicking the physiologic wound healing and reparative tissue processes. Despite an increase in PLG applications, the structures and kinetics of this autogenously derived biologic material have not been observed.

Methods: A review of the most recent literature was performed to evaluate the use of PLG in various surgical disciplines.

Results: The review showed that the application of PLG has been extended to various surgical disciplines including orthopedics, cardiac surgery, plastic and maxillofacial surgery, and recently also endoscopic surgery.

Conclusion: This review demonstrates the usefulness of PLG in a wide range of clinical applications for improvement of healing after surgical procedures.

Original language	English
Pages (from-to)	2063-2068
Number of pages	6
Journal	Surgical endoscopy and other interventional techniques
Volume	21
Issue number	11
DOIs	https://doi.org/10.1007/s00464-007-9293-x
Publication status	Published - Nov-2007

Keywords

growth factors
leukocytes
platelet gel
wound healing
MESENCHYMAL STEM-CELLS
RICH PLASMA
GROWTH-FACTORS
FIBRIN GLUE
MICROBICIDAL PROTEINS
BONE REGENERATION
REPAIR
PROLIFERATION
CONCENTRATE
DELIVERY

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Cite this

@article{1bbcb9991fb54bdc81a634fa75dedfaf,

title = "The use of autologous platelet-leukocyte gels to enhance the healing process in surgery, a review",

abstract = "Background: The therapeutic use of autologously prepared, platelet-leukocyte-enriched gel (PLG) is a relatively new technology for the stimulation and acceleration of soft tissue and bone healing. The effectiveness of this procedure lies in the delivery of a wide range of platelet growth factors mimicking the physiologic wound healing and reparative tissue processes. Despite an increase in PLG applications, the structures and kinetics of this autogenously derived biologic material have not been observed.Methods: A review of the most recent literature was performed to evaluate the use of PLG in various surgical disciplines.Results: The review showed that the application of PLG has been extended to various surgical disciplines including orthopedics, cardiac surgery, plastic and maxillofacial surgery, and recently also endoscopic surgery.Conclusion: This review demonstrates the usefulness of PLG in a wide range of clinical applications for improvement of healing after surgical procedures.",

keywords = "growth factors, leukocytes, platelet gel, wound healing, MESENCHYMAL STEM-CELLS, RICH PLASMA, GROWTH-FACTORS, FIBRIN GLUE, MICROBICIDAL PROTEINS, BONE REGENERATION, REPAIR, PROLIFERATION, CONCENTRATE, DELIVERY",

author = "Everts, {P. A.} and Overdevest, {E. P.} and Jakimowicz, {J. J.} and Oosterbos, {C. J.} and Schonberger, {J. P.} and Knape, {J. T.} and {van Zundert}, A.",

year = "2007",

month = nov,

doi = "10.1007/s00464-007-9293-x",

language = "English",

volume = "21",

pages = "2063--2068",

journal = "Surgical endoscopy and other interventional techniques",

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publisher = "Springer",

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T1 - The use of autologous platelet-leukocyte gels to enhance the healing process in surgery, a review

AU - Everts, P. A.

AU - Overdevest, E. P.

AU - Jakimowicz, J. J.

AU - Oosterbos, C. J.

AU - Schonberger, J. P.

AU - Knape, J. T.

AU - van Zundert, A.

PY - 2007/11

Y1 - 2007/11

N2 - Background: The therapeutic use of autologously prepared, platelet-leukocyte-enriched gel (PLG) is a relatively new technology for the stimulation and acceleration of soft tissue and bone healing. The effectiveness of this procedure lies in the delivery of a wide range of platelet growth factors mimicking the physiologic wound healing and reparative tissue processes. Despite an increase in PLG applications, the structures and kinetics of this autogenously derived biologic material have not been observed.Methods: A review of the most recent literature was performed to evaluate the use of PLG in various surgical disciplines.Results: The review showed that the application of PLG has been extended to various surgical disciplines including orthopedics, cardiac surgery, plastic and maxillofacial surgery, and recently also endoscopic surgery.Conclusion: This review demonstrates the usefulness of PLG in a wide range of clinical applications for improvement of healing after surgical procedures.

AB - Background: The therapeutic use of autologously prepared, platelet-leukocyte-enriched gel (PLG) is a relatively new technology for the stimulation and acceleration of soft tissue and bone healing. The effectiveness of this procedure lies in the delivery of a wide range of platelet growth factors mimicking the physiologic wound healing and reparative tissue processes. Despite an increase in PLG applications, the structures and kinetics of this autogenously derived biologic material have not been observed.Methods: A review of the most recent literature was performed to evaluate the use of PLG in various surgical disciplines.Results: The review showed that the application of PLG has been extended to various surgical disciplines including orthopedics, cardiac surgery, plastic and maxillofacial surgery, and recently also endoscopic surgery.Conclusion: This review demonstrates the usefulness of PLG in a wide range of clinical applications for improvement of healing after surgical procedures.

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KW - MESENCHYMAL STEM-CELLS

KW - RICH PLASMA

KW - GROWTH-FACTORS

KW - FIBRIN GLUE

KW - MICROBICIDAL PROTEINS

KW - BONE REGENERATION

KW - REPAIR

KW - PROLIFERATION

KW - CONCENTRATE

KW - DELIVERY

U2 - 10.1007/s00464-007-9293-x

DO - 10.1007/s00464-007-9293-x

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