The use of autologous platelet-leukocyte gels to enhance the healing process in surgery, a review

P. A. Everts*, E. P. Overdevest, J. J. Jakimowicz, C. J. Oosterbos, J. P. Schonberger, J. T. Knape, A. van Zundert

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

78 Citations (Scopus)

Abstract

Background: The therapeutic use of autologously prepared, platelet-leukocyte-enriched gel (PLG) is a relatively new technology for the stimulation and acceleration of soft tissue and bone healing. The effectiveness of this procedure lies in the delivery of a wide range of platelet growth factors mimicking the physiologic wound healing and reparative tissue processes. Despite an increase in PLG applications, the structures and kinetics of this autogenously derived biologic material have not been observed.

Methods: A review of the most recent literature was performed to evaluate the use of PLG in various surgical disciplines.

Results: The review showed that the application of PLG has been extended to various surgical disciplines including orthopedics, cardiac surgery, plastic and maxillofacial surgery, and recently also endoscopic surgery.

Conclusion: This review demonstrates the usefulness of PLG in a wide range of clinical applications for improvement of healing after surgical procedures.

Original languageEnglish
Pages (from-to)2063-2068
Number of pages6
JournalSurgical endoscopy and other interventional techniques
Volume21
Issue number11
DOIs
Publication statusPublished - Nov-2007

Keywords

  • growth factors
  • leukocytes
  • platelet gel
  • wound healing
  • MESENCHYMAL STEM-CELLS
  • RICH PLASMA
  • GROWTH-FACTORS
  • FIBRIN GLUE
  • MICROBICIDAL PROTEINS
  • BONE REGENERATION
  • REPAIR
  • PROLIFERATION
  • CONCENTRATE
  • DELIVERY

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