The use of positively charged or low surface free energy coatings versus polymer brushes in controlling biofilm formation

Astrid Roosjen, Willem Norde, Henny C. van der Mei, Henk J. Busscher*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

60 Citations (Scopus)

Abstract

Biofilm formation on biomaterials implant surfaces and subsequent infectious complications are a frequent reason for failure of many biomedical devices, such as total hip arthroplasties, vascular catheters and urinary catheters. The development of a biofilm is initiated by the formation of a conditioning film of adsorbed macromolecules, such as proteins, followed by adhesion of microorganisms, where after they grow and anchor through secretion of extracellular polymeric substances. Adhesion of microorganisms is influenced by the physico-chemical properties of the biomaterial surface. Positively charged materials stimulate bacterial adhesion, but prevent growth of adhering bacteria. The use of low surface free energy materials did not always reduce in vitro adhesion of bacteria, but has been found beneficial in in vivo applications where fluctuating shear forces prevail, like on intra-oral devices and urine catheters. Polymer brushes have shown a very high reduction in in vitro adhesion of a great variety of microorganisms. However, for clinical application, the long term stability of polymer brushes is still a limiting factor. Further effort is therefore required to enhance the stability of polymer brushes on biomaterial implant surfaces to facilitate clinical use of these promising coatings.

Original languageEnglish
Title of host publicationCharacterization of Polymer Surfaces and Thin FIlms
EditorsK Grundke, M Stamm, HJ Adler
Place of PublicationBERLIN
PublisherSpringer
Pages138-144
Number of pages7
ISBN (Print)3-540-31241-2
DOIs
Publication statusPublished - 2006
Event10th Dresden Polymer Meeting - , Germany
Duration: 10-Apr-200513-Apr-2005

Publication series

NamePROGRESS IN COLLOID AND POLYMER SCIENCE
PublisherSPRINGER-VERLAG BERLIN
Volume132
ISSN (Print)0340-255X

Other

Other10th Dresden Polymer Meeting
CountryGermany
Period10/04/200513/04/2005

Keywords

  • biofilm
  • biomaterial centered infection
  • microbial adhesion
  • polymer brushes
  • surface free energy
  • COAGULASE-NEGATIVE STAPHYLOCOCCI
  • POLY(ETHYLENE OXIDE) BRUSHES
  • SELF-ASSEMBLED MONOLAYERS
  • BACTERIAL ADHESION
  • POLYETHYLENE-GLYCOL
  • PROTEIN ADSORPTION
  • POLYSTYRENE SURFACES
  • BIOMEDICAL POLYMERS
  • MICROBIAL ADHESION
  • PARALLEL-PLATE

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