The use of the GBI as predictor of bipolar disorder in a population of adolescent offspring of parents with a bipolar disorder

CG Reichart*, J van der Ende, M Wals, MHJ Hillegers, WA Nolen, J Ormel, FC Verhulst

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Abstract

Objective: To assess the usefulness of the General Behavior Inventory (GBI) to predict the development of mood disorders in the offspring of parents with bipolar disorder. Method: The GBI and the K-SADS (first measurement) and the SCID (last measurement) were used to assess psychopathology among 129 adolescent and young adult offspring of a bipolar parent with an interval of 5 years. Based on the SCID results at the last measurement, the offspring were assigned to one of four groups: with bipolar mood disorder, with unipolar mood disorders, with non-mood disorders and without disorders and GBI-scores at the first measurement were compared across the four groups. Results: The scores on the Depression scale of the GBI for the offspring who later developed a bipolar or any mood disorder were significantly higher than for the offspring who did not develop a mood disorder across a 5-year interval. For the offspring with a unipolar mood disorder at the first measurement, the scores on the Depression scale were significantly higher for those who switched to bipolar disorder versus those who remained unipolar. Conclusions: The GBI can be used in a high-risk sample of offspring of parents with bipolar disorder as a self-report measure as an aid to detect those who will develop bipolar disorder across a 5-year interval. (c) 2005 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalJournal of Affective Disorders
Volume89
Issue number1-3
DOIs
Publication statusPublished - Dec-2005

Keywords

  • bipolar disorder
  • offspring
  • adolescents
  • General Behavior Inventory (GBI)
  • GENERAL BEHAVIOR INVENTORY
  • DISCRIMINATIVE VALIDITY
  • COMMUNITY SAMPLE
  • CHILDREN
  • PSYCHOPATHOLOGY
  • VALIDATION
  • SYMPTOMS
  • IDENTIFICATION
  • CYCLOTHYMIA
  • RISK

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