The validity of circulating microRNAs in oncology: five years of challenges and contradictions

J Jarry; D Schadendorf; C Greenwood; A Spatz; L C van Kempen

doi:10.1016/j.molonc.2014.02.009

The validity of circulating microRNAs in oncology: five years of challenges and contradictions

J Jarry, D Schadendorf, C Greenwood, A Spatz, L C van Kempen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

MicroRNAs (miRNAs) in circulation have received an increasing amount of interest as potential minimal invasive diagnostic tools in oncology. Several diagnostic, prognostic and predictive signatures have been proposed for a variety of cancers at different stages of disease, but these have not been subjected to a critical review regarding their validity: reproducible identification in comparable studies and/or with different platforms of miRNA detection. In this review, we will critically address the results of circulating miRNA research in oncology that have been published between January 2008 and June 2013 (5.5 years), and discuss pre-analytical challenges, technological pitfalls and limitations that may contribute to the non-reproducibility of circulating miRNA research.

Original language	English
Pages (from-to)	819-829
Number of pages	11
Journal	Molecular oncology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.molonc.2014.02.009
Publication status	Published - Jun-2014
Externally published	Yes

Keywords

Biomarkers, Tumor/genetics
Blood Chemical Analysis/methods
Humans
Medical Oncology/methods
MicroRNAs/blood
Neoplasms/blood
Polymerase Chain Reaction/methods
Prognosis
Reproducibility of Results
Transcriptome

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The validity of circulating microRNAs in oncology_ Five years of challenges and contradictionsFinal publisher's version, 729 KBLicence: CC BY

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title = "The validity of circulating microRNAs in oncology: five years of challenges and contradictions",

abstract = "MicroRNAs (miRNAs) in circulation have received an increasing amount of interest as potential minimal invasive diagnostic tools in oncology. Several diagnostic, prognostic and predictive signatures have been proposed for a variety of cancers at different stages of disease, but these have not been subjected to a critical review regarding their validity: reproducible identification in comparable studies and/or with different platforms of miRNA detection. In this review, we will critically address the results of circulating miRNA research in oncology that have been published between January 2008 and June 2013 (5.5 years), and discuss pre-analytical challenges, technological pitfalls and limitations that may contribute to the non-reproducibility of circulating miRNA research. ",

keywords = "Biomarkers, Tumor/genetics, Blood Chemical Analysis/methods, Humans, Medical Oncology/methods, MicroRNAs/blood, Neoplasms/blood, Polymerase Chain Reaction/methods, Prognosis, Reproducibility of Results, Transcriptome",

author = "J Jarry and D Schadendorf and C Greenwood and A Spatz and {van Kempen}, {L C}",

year = "2014",

month = jun,

doi = "10.1016/j.molonc.2014.02.009",

language = "English",

volume = "8",

pages = "819--829",

journal = "Molecular oncology",

issn = "1574-7891",

publisher = "Wiley",

number = "4",

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TY - JOUR

T1 - The validity of circulating microRNAs in oncology

T2 - five years of challenges and contradictions

AU - Jarry, J

AU - Schadendorf, D

AU - Greenwood, C

AU - Spatz, A

AU - van Kempen, L C

PY - 2014/6

Y1 - 2014/6

N2 - MicroRNAs (miRNAs) in circulation have received an increasing amount of interest as potential minimal invasive diagnostic tools in oncology. Several diagnostic, prognostic and predictive signatures have been proposed for a variety of cancers at different stages of disease, but these have not been subjected to a critical review regarding their validity: reproducible identification in comparable studies and/or with different platforms of miRNA detection. In this review, we will critically address the results of circulating miRNA research in oncology that have been published between January 2008 and June 2013 (5.5 years), and discuss pre-analytical challenges, technological pitfalls and limitations that may contribute to the non-reproducibility of circulating miRNA research.

AB - MicroRNAs (miRNAs) in circulation have received an increasing amount of interest as potential minimal invasive diagnostic tools in oncology. Several diagnostic, prognostic and predictive signatures have been proposed for a variety of cancers at different stages of disease, but these have not been subjected to a critical review regarding their validity: reproducible identification in comparable studies and/or with different platforms of miRNA detection. In this review, we will critically address the results of circulating miRNA research in oncology that have been published between January 2008 and June 2013 (5.5 years), and discuss pre-analytical challenges, technological pitfalls and limitations that may contribute to the non-reproducibility of circulating miRNA research.

KW - Biomarkers, Tumor/genetics

KW - Blood Chemical Analysis/methods

KW - Humans

KW - Medical Oncology/methods

KW - MicroRNAs/blood

KW - Neoplasms/blood

KW - Polymerase Chain Reaction/methods

KW - Prognosis

KW - Reproducibility of Results

KW - Transcriptome

U2 - 10.1016/j.molonc.2014.02.009

DO - 10.1016/j.molonc.2014.02.009

M3 - Review article

C2 - 24656978

SN - 1574-7891

VL - 8

SP - 819

EP - 829

JO - Molecular oncology

JF - Molecular oncology

IS - 4

ER -

The validity of circulating microRNAs in oncology: five years of challenges and contradictions

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