The Virosome concept in influenza vaccines

J Wilschut*, A Huckriede, L Bungener, T Daemen, T Stegmann, A Palache

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Reconstituted influenza virus envelopes (virosomes) represent efficient influenza vaccines inducing high antibody titers upon intramuscular adminsitration. Virosomes are reconstituted viral envelopes which retain the cell entry and membrane fusion characteristics of native influenza virus. Here, we show that virosomes, by virtue of their membrane fusion activity, have the capacity to deliver a virosome-encapsulated protein antigen (ovalbumin, OVA) to the cytosol of cultured murine bone-marrow-derived dendritic cells (DCs) and thus to the MHC class I presentation pathway. Accordingly, immunization of mice with OVA-containing virosomes resulted in efficient priming of an OVA-specific class I MHC-restricted cytotoxic T lymphocyte (CTL) response. These results indicate that virosomes have the capacity to prime a broad immune response, inducing not only humoral but also cellular immunity.

Original languageEnglish
Title of host publicationIMMUNOLOGY 2004: IMMUNODEFICIENCY, INFECTIOUS DISEASES, IMMUNOMODULATION, AND VACCINES
Place of PublicationBOLOGNA
PublisherMEDIMOND PUBLISHING CO
Pages521-525
Number of pages5
ISBN (Print)88-7587-075-6
Publication statusPublished - 2004
Event12th Annual International Congress of Immunology/4th Annual Conference of the Federation-of-Clinical-Immunology-Societies (FOCIS) - , Canada
Duration: 18-Jul-200423-Jul-2004

Other

Other12th Annual International Congress of Immunology/4th Annual Conference of the Federation-of-Clinical-Immunology-Societies (FOCIS)
Country/TerritoryCanada
Period18/07/200423/07/2004

Keywords

  • VIRUS ENVELOPES

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