The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings

Vera Rogiers*, Emilio Benfenati, Ulrike Bernauer, Laurent Bodin, Paul Carmichael, Qasim Chaudhry, Pieter Jan Coenraads, Mark T. D. Cronin, Matthew Dent, Maria Dusinska, Corie Ellison, Janine Ezendam, Eric Gaffet, Corrado Lodovico Galli, Carsten Goebel, Berit Granum, Heli Miriam Hollnagel, Petra S. Kern, Kirstin Kosemund-Meynen, Gladys OuedraogoEirini Panteri, Christophe Rousselle, Maciej Stepnik, Tamara Vanhaecke, Natalie von Goetz, Andrew Worth

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)

    Abstract

    Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This means that for the safety assessment of cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called "Replacement methods". In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of "New Approach Methodology" that could be useful tools in the context of the "Next Generation Risk Assessment" and the strategic framework for safety assessment of cosmetics were discussed in depth.

    Original languageEnglish
    Article number152421
    Number of pages14
    JournalToxicology
    Volume436
    DOIs
    Publication statusPublished - 30-Apr-2020

    Keywords

    • Cosmetics
    • New approach methodology
    • Animal-Free method
    • Replacement method
    • Alternative method
    • Next generation risk assessment
    • Safety assessment
    • TOXICOLOGICAL CONCERN VALUES
    • DEVELOPMENTAL TOXICITY
    • READ-ACROSS
    • CONCERN TTC
    • THRESHOLD
    • SUBSTANCES
    • EXPOSURE
    • RISK
    • IDENTIFICATION
    • UNCERTAINTY

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