Theoretical analysis of human muscle membrane behavior in hypokalemic periodic paralysis

Martin J. Alberink*, Willemien Wallinga, Henk Wolters, Dirk L. Ypey, Thera P. Links, Herman B.K. Boom

*Corresponding author for this work

Research output: Contribution to conferencePaperAcademic

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Abstract

Computer simulations were performed to investigate the behavior of human muscle membrane with membrane defects supposed to be present in the muscular disease Hypokalemic Periodic Paralysis (HOPP). The model used for simulation was a Hodgkin-Huxley model. The T-tubular system was also incorporated. It was studied whether the membrane defects caused the following recorded HOPP phenomena: a slight depolarization of a HOPP muscle cell when serum potassium is normal and a strong depolarization to -50 mV when serum potassium is low. In our model a constant small sodium leak conductance slightly depolarized the cell, whereas a small fraction of noninactivating sodium channels caused a strong depolarization. In the case of a dependency of this fraction on serum potassium according to a Boltzmann relation such a depolarization occurred only when serum potassium was low. In our simulations, the resting membrane potential moved from -90 mV to -30 mV after a single action potential when 8% or more of the sodium channels did not inactivate. Our results were qualitatively similar when the T-tubular system was decoupled.

Original languageEnglish
Pages1493-1494
Number of pages2
DOIs
Publication statusPublished - 1-Dec-1995
Externally publishedYes
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: 20-Sep-199523-Sep-1995

Conference

ConferenceProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)
CityMontreal, Can
Period20/09/199523/09/1995

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