Computer simulations were performed to investigate the behavior of human muscle membrane with membrane defects supposed to be present in the muscular disease Hypokalemic Periodic Paralysis (HOPP). The model used for simulation was a Hodgkin-Huxley model. The T-tubular system was also incorporated. It was studied whether the membrane defects caused the following recorded HOPP phenomena: a slight depolarization of a HOPP muscle cell when serum potassium is normal and a strong depolarization to -50 mV when serum potassium is low. In our model a constant small sodium leak conductance slightly depolarized the cell, whereas a small fraction of noninactivating sodium channels caused a strong depolarization. In the case of a dependency of this fraction on serum potassium according to a Boltzmann relation such a depolarization occurred only when serum potassium was low. In our simulations, the resting membrane potential moved from -90 mV to -30 mV after a single action potential when 8% or more of the sodium channels did not inactivate. Our results were qualitatively similar when the T-tubular system was decoupled.
|Number of pages||2|
|Publication status||Published - 1-Dec-1995|
|Event||Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can|
Duration: 20-Sep-1995 → 23-Sep-1995
|Conference||Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)|
|Period||20/09/1995 → 23/09/1995|