Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke

Ewelina Kurtys, Cindy Casteels, Caroline C Real, Ulrich L M Eisel, J Martin Verkuyl, Laus M Broersen, Hans C Klein, Rudi A J O Dierckx, Janine Doorduin, Erik F J de Vries

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Abstract

INTRODUCTION: A possible target for stroke management is modulation of neuroinflammation. Evidence suggests that food components may exert anti-inflammatory properties and thus may reduce stroke-induced brain damage.

AIM: To investigate the efficacy of a diet, containing anti-inflammatory ingredients, as treatment for focal ischemic brain damage induced by photothrombotic stroke in the somatosensory cortex of rats.

RESULTS: Brain lesions were surrounded by strong astrogliosis on both day 7 and day 21 after stroke and were accompanied by a trend toward globally decreased glucose metabolism on day 7. The investigational diet applied 2 weeks before the ischemia did not affect astrocyte activation on day 7, but reduced it at day 21. The investigational diet applied immediately after the ischemia, increased astrocyte activation on day 7 and completely reversed this effect on day 21. Moreover, postischemic intervention increased glucose metabolism in somatosensory cortex ipsilateral to the lesion on day 7.

CONCLUSION: This study reveals potentially beneficial effects of a diet containing elevated amounts of anti-inflammatory nutrients on the recovery from ischemic brain damage. Therefore, dietary intervention can be considered as an adjuvant therapy for recovery from this brain pathology.

Original languageEnglish
Pages (from-to)36-46
Number of pages11
JournalCNS Neuroscience & Therapeutics
Volume25
Issue number1
DOIs
Publication statusPublished - Jan-2019

Keywords

  • neuroinflammation
  • nutrition
  • PET imaging
  • photothrombotic stroke
  • CEREBRAL-ISCHEMIA
  • PROTEIN SUPPLEMENTATION
  • CYTOKINE PRODUCTION
  • RECOVERY
  • RISK
  • MECHANISMS
  • PREVENTION
  • INSTITUTE
  • ACID

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