Therapeutic immunization strategies against cervical cancer: induction of cell-mediated immunity in murine models

Laura Barbara Bungener

Therapeutic immunization strategies against cervical cancer: induction of cell-mediated immunity in murine models

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Abstract

The aim of the study described in this thesis is the development of a therapeutic immunization strategy against cervical cancer and pre-malignant precursor lesions of cervical cancer (CIN lesions). Cervical cancer is caused by high risk human papillomavirus (HPV). Two of the early proteins of high risk HPV, E6 and E7, interact with the cell cycle regulation proteins p53 and pRb and can cause immortalization of cells. E6 and E7 are constitutively expressed by cervical cancer cells, making these proteins attractive targets for an immunotherapy directed against HPV-induced cervical cancer. In this thesis two strategies for effective induction of immune responses against protein antigens are explored: immunization with recombinant Semliki Forest virus (rSFV) and influenza virosomes containing protein antigens. Furthermore, the underlying mechanisms of cytotoxic T lymphocyte (CTL) induction by these immunizations are investigated.

Original language	English
Qualification	Doctor of Philosophy
Supervisors/Advisors	Wilschut, Jan, Supervisor Daemen, Toos, Co-supervisor
Publisher	s.n.
Print ISBNs	9064643040
Publication status	Published - 2004

Keywords

44.92 gynaecologie en obstetrie
Proefschriften (vorm)
Baarmoederhalskanker, Immuunreacties, Therapieën

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title = "Therapeutic immunization strategies against cervical cancer: induction of cell-mediated immunity in murine models",

abstract = "The aim of the study described in this thesis is the development of a therapeutic immunization strategy against cervical cancer and pre-malignant precursor lesions of cervical cancer (CIN lesions). Cervical cancer is caused by high risk human papillomavirus (HPV). Two of the early proteins of high risk HPV, E6 and E7, interact with the cell cycle regulation proteins p53 and pRb and can cause immortalization of cells. E6 and E7 are constitutively expressed by cervical cancer cells, making these proteins attractive targets for an immunotherapy directed against HPV-induced cervical cancer. In this thesis two strategies for effective induction of immune responses against protein antigens are explored: immunization with recombinant Semliki Forest virus (rSFV) and influenza virosomes containing protein antigens. Furthermore, the underlying mechanisms of cytotoxic T lymphocyte (CTL) induction by these immunizations are investigated.",

keywords = "44.92 gynaecologie en obstetrie, Proefschriften (vorm), Baarmoederhalskanker, Immuunreacties, Therapie{\"e}n",

author = "Bungener, \{Laura Barbara\}",

note = "date\_submitted:2004 Rights: University of Groningen",

year = "2004",

language = "English",

isbn = "9064643040",

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TY - BOOK

T1 - Therapeutic immunization strategies against cervical cancer

T2 - induction of cell-mediated immunity in murine models

AU - Bungener, Laura Barbara

N1 - date_submitted:2004 Rights: University of Groningen

PY - 2004

Y1 - 2004

N2 - The aim of the study described in this thesis is the development of a therapeutic immunization strategy against cervical cancer and pre-malignant precursor lesions of cervical cancer (CIN lesions). Cervical cancer is caused by high risk human papillomavirus (HPV). Two of the early proteins of high risk HPV, E6 and E7, interact with the cell cycle regulation proteins p53 and pRb and can cause immortalization of cells. E6 and E7 are constitutively expressed by cervical cancer cells, making these proteins attractive targets for an immunotherapy directed against HPV-induced cervical cancer. In this thesis two strategies for effective induction of immune responses against protein antigens are explored: immunization with recombinant Semliki Forest virus (rSFV) and influenza virosomes containing protein antigens. Furthermore, the underlying mechanisms of cytotoxic T lymphocyte (CTL) induction by these immunizations are investigated.

AB - The aim of the study described in this thesis is the development of a therapeutic immunization strategy against cervical cancer and pre-malignant precursor lesions of cervical cancer (CIN lesions). Cervical cancer is caused by high risk human papillomavirus (HPV). Two of the early proteins of high risk HPV, E6 and E7, interact with the cell cycle regulation proteins p53 and pRb and can cause immortalization of cells. E6 and E7 are constitutively expressed by cervical cancer cells, making these proteins attractive targets for an immunotherapy directed against HPV-induced cervical cancer. In this thesis two strategies for effective induction of immune responses against protein antigens are explored: immunization with recombinant Semliki Forest virus (rSFV) and influenza virosomes containing protein antigens. Furthermore, the underlying mechanisms of cytotoxic T lymphocyte (CTL) induction by these immunizations are investigated.

KW - 44.92 gynaecologie en obstetrie

KW - Proefschriften (vorm)

KW - Baarmoederhalskanker, Immuunreacties, Therapieën

M3 - Thesis fully internal (DIV)

SN - 9064643040

PB - s.n.

ER -

Therapeutic immunization strategies against cervical cancer: induction of cell-mediated immunity in murine models

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