Therapeutic interventions for aging: The case of cellular senescence

Abel Soto-Gamez, Marco Demaria*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

77 Citations (Scopus)
474 Downloads (Pure)

Abstract

Organismal aging is a multifactorial process characterized by the onset of degenerative conditions and cancer. One of the key drivers of aging is cellular senescence, a state of irreversible growth arrest induced by many pro-tumorigenic stresses. Senescent cells accumulate late in life and at sites of age-related pathologies, where they contribute to disease onset and progression through complex cell and non-cell autonomous effects. Here, we summarize the mechanisms by which cellular senescence can promote aging, and we offer an extensive description of current potential pharmacological interventions for senescent cells, highlighting limitations and suggesting alternatives.

Original languageEnglish
Pages (from-to)786-795
Number of pages10
JournalDrug Discovery Today
Volume22
Issue number5
DOIs
Publication statusPublished - May-2017

Keywords

  • DNA-DAMAGE RESPONSE
  • NF-KAPPA-B
  • PLASMINOGEN-ACTIVATOR INHIBITOR-1
  • MESENCHYMAL STEM-CELLS
  • SECRETORY PHENOTYPE
  • CANCER-THERAPY
  • LIFE-SPAN
  • IN-VIVO
  • HUMAN FIBROBLASTS
  • NKG2D RECEPTOR

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