Three-dimensional cross-linked F-actin networks: Relation between network architecture and mechanical behavior

E. M. Huisman*, T. van Dillen, P. R. Onck, E. Van der Giessen

*Corresponding author for this work

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Numerical simulations are reported for the response of three-dimensional cross-linked F-actin networks when subjected to large deformations. In addition to the physiological parameters such as actin and cross-linker concentration, the model explicitly accounts for filament properties and network architecture. Complementary to two-dimensional studies, we find that the strain-stiffening characteristics depend on network architecture through the local topology around cross-links.

Original languageEnglish
Article number208103
Number of pages4
JournalPhysical Review Letters
Issue number20
Publication statusPublished - 16-Nov-2007


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