Three times as many lamina I neurons project to the periaqueductal gray than to the thalamus: a retrograde tracing study in the cat

Leonora J. Mouton, Gert Holstege

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The number and distribution of lamina I neurons projecting to the periaqueductal gray (PAG) were examined by a retrograde tracing study in the cat. WGA-HRP injections in the intermediate and caudal FAG resulted in as much as 1600 labeled lamina I neurons throughout the length of the spinal cord, counted in a 1:4 series of sections. The lamina I-PAG projection was predominantly contralateral and most labeled lamina I neurons were found in the enlargements. Comparing these results with the number of lamina I-thalamic neurons leads to the conclusion that in the cat about three times as many lamina I neurons project to the FAG than to the thalamus. Considering this, one can conclude that the spino-PAG system is a virtually neglected area in pain research. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalNeuroscience Letters
Volume255
Issue number2
DOIs
Publication statusPublished - 16-Oct-1998

Keywords

  • lamina I
  • spinomesencephalic
  • periaqueductal gray
  • spinothalamic
  • nociception
  • cat
  • SPINAL-CORD
  • RAT
  • PRIMATE
  • ORIGIN
  • CELLS
  • COLLATERALS
  • MONKEY
  • INPUT

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