Thymic epithelial turnours: A population-based study of the incidence, diagnostic procedures and therapy

Wouter K. de Jong; Johannes L. G. Blaauwgeers; Michael Schaapveld; Wim Timens; Theo J. Klinkenberg; Harry J. M. Groen

doi:10.1016/j.ejca.2007.11.004

Thymic epithelial turnours: A population-based study of the incidence, diagnostic procedures and therapy

Wouter K. de Jong^*, Johannes L. G. Blaauwgeers, Michael Schaapveld, Wim Timens, Theo J. Klinkenberg, Harry J. M. Groen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The population-based incidence, diagnostic procedures, therapy and survival of thymic epithelial tumours were determined using the Netherlands National Pathological Archives and the Netherlands Cancer Registry. Excess mortality compared to the Netherlands standard population was estimated by relative survival analysis.

Between 1994 and 2003, 537 thymic epithelial tumours were diagnosed. The incidence of all thymic epithelial tumours was 3.2/1,000,000. Diagnosis was obtained by primary resection in 56% of cases. Survival data were available for 232 cases. Not only thymic carcinomas (type C) but also thymomas (types B1-B3) were associated with excess mortality. Cases that underwent resection (78%) had a better survival than non-operated cases (median survival >10 years versus 1.1 years, p <0.001). Amongst the surgically treated cases (n = 180), the completeness of resection did not predict survival (p = 0.53).

Thymic epithelial tumours are rare. Excess mortality was observed in the majority of tumours. Surgery offers the best perspectives, even if the resection is incomplete. (c) 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	123-130
Number of pages	8
Journal	European Journal of Cancer
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/j.ejca.2007.11.004
Publication status	Published - Jan-2008
Event	43rd Annual Meeting of the American-Society-of-Clinical-Oncology - , Israel Duration: 1-Jun-2007 → 5-Jun-2007

Keywords

thymic epithelial tumour
population-based study
incidence
diagnosis
therapy
survival
ORGANIZATION HISTOLOGIC CLASSIFICATION
TRANSTHORACIC NEEDLE-BIOPSY
MALIGNANT THYMOMA
TUMORS
SURVIVAL
PREDICTORS
RECURRENCE
PROGNOSIS
NEOPLASMS

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@article{37837a50ba604ebfa6cb619afa69245f,

title = "Thymic epithelial turnours: A population-based study of the incidence, diagnostic procedures and therapy",

abstract = "The population-based incidence, diagnostic procedures, therapy and survival of thymic epithelial tumours were determined using the Netherlands National Pathological Archives and the Netherlands Cancer Registry. Excess mortality compared to the Netherlands standard population was estimated by relative survival analysis.Between 1994 and 2003, 537 thymic epithelial tumours were diagnosed. The incidence of all thymic epithelial tumours was 3.2/1,000,000. Diagnosis was obtained by primary resection in 56% of cases. Survival data were available for 232 cases. Not only thymic carcinomas (type C) but also thymomas (types B1-B3) were associated with excess mortality. Cases that underwent resection (78%) had a better survival than non-operated cases (median survival >10 years versus 1.1 years, p <0.001). Amongst the surgically treated cases (n = 180), the completeness of resection did not predict survival (p = 0.53).Thymic epithelial tumours are rare. Excess mortality was observed in the majority of tumours. Surgery offers the best perspectives, even if the resection is incomplete. (c) 2007 Elsevier Ltd. All rights reserved.",

keywords = "thymic epithelial tumour, population-based study, incidence, diagnosis, therapy, survival, ORGANIZATION HISTOLOGIC CLASSIFICATION, TRANSTHORACIC NEEDLE-BIOPSY, MALIGNANT THYMOMA, TUMORS, SURVIVAL, PREDICTORS, RECURRENCE, PROGNOSIS, NEOPLASMS",

author = "{de Jong}, {Wouter K.} and Blaauwgeers, {Johannes L. G.} and Michael Schaapveld and Wim Timens and Klinkenberg, {Theo J.} and Groen, {Harry J. M.}",

year = "2008",

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doi = "10.1016/j.ejca.2007.11.004",

language = "English",

volume = "44",

pages = "123--130",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "ELSEVIER SCI LTD",

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note = "43rd Annual Meeting of the American-Society-of-Clinical-Oncology ; Conference date: 01-06-2007 Through 05-06-2007",

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AU - de Jong, Wouter K.

AU - Blaauwgeers, Johannes L. G.

AU - Schaapveld, Michael

AU - Timens, Wim

AU - Klinkenberg, Theo J.

AU - Groen, Harry J. M.

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N2 - The population-based incidence, diagnostic procedures, therapy and survival of thymic epithelial tumours were determined using the Netherlands National Pathological Archives and the Netherlands Cancer Registry. Excess mortality compared to the Netherlands standard population was estimated by relative survival analysis.Between 1994 and 2003, 537 thymic epithelial tumours were diagnosed. The incidence of all thymic epithelial tumours was 3.2/1,000,000. Diagnosis was obtained by primary resection in 56% of cases. Survival data were available for 232 cases. Not only thymic carcinomas (type C) but also thymomas (types B1-B3) were associated with excess mortality. Cases that underwent resection (78%) had a better survival than non-operated cases (median survival >10 years versus 1.1 years, p <0.001). Amongst the surgically treated cases (n = 180), the completeness of resection did not predict survival (p = 0.53).Thymic epithelial tumours are rare. Excess mortality was observed in the majority of tumours. Surgery offers the best perspectives, even if the resection is incomplete. (c) 2007 Elsevier Ltd. All rights reserved.

AB - The population-based incidence, diagnostic procedures, therapy and survival of thymic epithelial tumours were determined using the Netherlands National Pathological Archives and the Netherlands Cancer Registry. Excess mortality compared to the Netherlands standard population was estimated by relative survival analysis.Between 1994 and 2003, 537 thymic epithelial tumours were diagnosed. The incidence of all thymic epithelial tumours was 3.2/1,000,000. Diagnosis was obtained by primary resection in 56% of cases. Survival data were available for 232 cases. Not only thymic carcinomas (type C) but also thymomas (types B1-B3) were associated with excess mortality. Cases that underwent resection (78%) had a better survival than non-operated cases (median survival >10 years versus 1.1 years, p <0.001). Amongst the surgically treated cases (n = 180), the completeness of resection did not predict survival (p = 0.53).Thymic epithelial tumours are rare. Excess mortality was observed in the majority of tumours. Surgery offers the best perspectives, even if the resection is incomplete. (c) 2007 Elsevier Ltd. All rights reserved.

KW - thymic epithelial tumour

KW - population-based study

KW - incidence

KW - diagnosis

KW - therapy

KW - survival

KW - ORGANIZATION HISTOLOGIC CLASSIFICATION

KW - TRANSTHORACIC NEEDLE-BIOPSY

KW - MALIGNANT THYMOMA

KW - TUMORS

KW - SURVIVAL

KW - PREDICTORS

KW - RECURRENCE

KW - PROGNOSIS

KW - NEOPLASMS

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DO - 10.1016/j.ejca.2007.11.004

M3 - Article

SN - 0959-8049

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JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 1

Y2 - 1 June 2007 through 5 June 2007

ER -

Thymic epithelial turnours: A population-based study of the incidence, diagnostic procedures and therapy

Abstract

Keywords

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