Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: Analysis of three European mother-child cohorts

Marijke de Cock; Michiel R. de Boer; Eva Govarts; Nina Iszatt; Lubica Palkovicova; Marja H. Lamoree; Greet Schoeters; Merete Eggesbø; Tomas Trnovec; Juliette Legler; Margot van de Bor

doi:10.1038/pr.2017.50

Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: Analysis of three European mother-child cohorts

Marijke de Cock^*, Michiel R. de Boer, Eva Govarts, Nina Iszatt, Lubica Palkovicova, Marja H. Lamoree, Greet Schoeters, Merete Eggesbø, Tomas Trnovec, Juliette Legler, Margot van de Bor

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

19 Citations (Scopus)

Abstract

Background: Various studies have reported interactions between thyroid hormones and early life chemical exposure. Our objective was to analyze the associations between markers of endocrine-disrupting chemical exposure and thyroid function in newborns, determined through heel prick blood spots.

Methods: Three European mother-child cohorts (FLEHSI - Belgium, HUMIS - Norway, and the PCB cohort - Slovakia. Total n=1,784) were pooled for the purpose of this study. Data on thyroid-stimulating hormone (TSH) were obtained from national neonatal screening registries, and samples of cord plasma and/or breast milk were collected to determine exposure to various chemicals. Multiple regression models were composed with exposure and cohort as fixed factors, and adjustments were made for a priori defined covariates.

Results: Median TSH concentrations were 1, 1.10, and 2.76 mU/l for the Belgian, Norwegian, and Slovak cohorts, respectively. For polychlorinated biphenyl (PCB)-153 and dichlorodiphenyldichloroethylene (p,p′-DDE), children in the third exposure quartile had a 12-15% lower TSH at birth. Results remained unchanged after additional adjustment for birth weight and gestational weight gain. No effect on TSH was observed for the other compounds.

Conclusion: Early life exposure to PCB-153 and p,p′-DDE impacts newborn TSH levels. Higher exposure levels were associated with 12-15% lower TSH levels.

Original language	English
Pages (from-to)	429-437
Number of pages	9
Journal	Pediatric Research
Volume	82
Issue number	3
DOIs	https://doi.org/10.1038/pr.2017.50
Publication status	Published - 1-Sept-2017
Externally published	Yes

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de Cock, M., de Boer, M. R., Govarts, E., Iszatt, N., Palkovicova, L., Lamoree, M. H., Schoeters, G., Eggesbø, M., Trnovec, T., Legler, J., & van de Bor, M. (2017). Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: Analysis of three European mother-child cohorts. Pediatric Research, 82(3), 429-437. https://doi.org/10.1038/pr.2017.50

@article{291a5f5aa75c4211a9c8e68cb93a894c,

title = "Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: Analysis of three European mother-child cohorts",

abstract = "Background: Various studies have reported interactions between thyroid hormones and early life chemical exposure. Our objective was to analyze the associations between markers of endocrine-disrupting chemical exposure and thyroid function in newborns, determined through heel prick blood spots.Methods: Three European mother-child cohorts (FLEHSI - Belgium, HUMIS - Norway, and the PCB cohort - Slovakia. Total n=1,784) were pooled for the purpose of this study. Data on thyroid-stimulating hormone (TSH) were obtained from national neonatal screening registries, and samples of cord plasma and/or breast milk were collected to determine exposure to various chemicals. Multiple regression models were composed with exposure and cohort as fixed factors, and adjustments were made for a priori defined covariates.Results: Median TSH concentrations were 1, 1.10, and 2.76 mU/l for the Belgian, Norwegian, and Slovak cohorts, respectively. For polychlorinated biphenyl (PCB)-153 and dichlorodiphenyldichloroethylene (p,p′-DDE), children in the third exposure quartile had a 12-15% lower TSH at birth. Results remained unchanged after additional adjustment for birth weight and gestational weight gain. No effect on TSH was observed for the other compounds.Conclusion: Early life exposure to PCB-153 and p,p′-DDE impacts newborn TSH levels. Higher exposure levels were associated with 12-15% lower TSH levels.",

author = "{de Cock}, Marijke and {de Boer}, {Michiel R.} and Eva Govarts and Nina Iszatt and Lubica Palkovicova and Lamoree, {Marja H.} and Greet Schoeters and Merete Eggesb{\o} and Tomas Trnovec and Juliette Legler and {van de Bor}, Margot",

note = "Funding Information: This research was funded by the European Community{\textquoteright}s Seventh Framework Program [FP7/2007-2013] under Grant Agreement OBELIX No. 227391.",

year = "2017",

month = sep,

day = "1",

doi = "10.1038/pr.2017.50",

language = "English",

volume = "82",

pages = "429--437",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "Nature Publishing Group",

number = "3",

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de Cock, M, de Boer, MR, Govarts, E, Iszatt, N, Palkovicova, L, Lamoree, MH, Schoeters, G, Eggesbø, M, Trnovec, T, Legler, J & van de Bor, M 2017, 'Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: Analysis of three European mother-child cohorts', Pediatric Research, vol. 82, no. 3, pp. 429-437. https://doi.org/10.1038/pr.2017.50

TY - JOUR

T1 - Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals

T2 - Analysis of three European mother-child cohorts

AU - de Cock, Marijke

AU - de Boer, Michiel R.

AU - Govarts, Eva

AU - Iszatt, Nina

AU - Palkovicova, Lubica

AU - Lamoree, Marja H.

AU - Schoeters, Greet

AU - Eggesbø, Merete

AU - Trnovec, Tomas

AU - Legler, Juliette

AU - van de Bor, Margot

N1 - Funding Information: This research was funded by the European Community’s Seventh Framework Program [FP7/2007-2013] under Grant Agreement OBELIX No. 227391.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background: Various studies have reported interactions between thyroid hormones and early life chemical exposure. Our objective was to analyze the associations between markers of endocrine-disrupting chemical exposure and thyroid function in newborns, determined through heel prick blood spots.Methods: Three European mother-child cohorts (FLEHSI - Belgium, HUMIS - Norway, and the PCB cohort - Slovakia. Total n=1,784) were pooled for the purpose of this study. Data on thyroid-stimulating hormone (TSH) were obtained from national neonatal screening registries, and samples of cord plasma and/or breast milk were collected to determine exposure to various chemicals. Multiple regression models were composed with exposure and cohort as fixed factors, and adjustments were made for a priori defined covariates.Results: Median TSH concentrations were 1, 1.10, and 2.76 mU/l for the Belgian, Norwegian, and Slovak cohorts, respectively. For polychlorinated biphenyl (PCB)-153 and dichlorodiphenyldichloroethylene (p,p′-DDE), children in the third exposure quartile had a 12-15% lower TSH at birth. Results remained unchanged after additional adjustment for birth weight and gestational weight gain. No effect on TSH was observed for the other compounds.Conclusion: Early life exposure to PCB-153 and p,p′-DDE impacts newborn TSH levels. Higher exposure levels were associated with 12-15% lower TSH levels.

AB - Background: Various studies have reported interactions between thyroid hormones and early life chemical exposure. Our objective was to analyze the associations between markers of endocrine-disrupting chemical exposure and thyroid function in newborns, determined through heel prick blood spots.Methods: Three European mother-child cohorts (FLEHSI - Belgium, HUMIS - Norway, and the PCB cohort - Slovakia. Total n=1,784) were pooled for the purpose of this study. Data on thyroid-stimulating hormone (TSH) were obtained from national neonatal screening registries, and samples of cord plasma and/or breast milk were collected to determine exposure to various chemicals. Multiple regression models were composed with exposure and cohort as fixed factors, and adjustments were made for a priori defined covariates.Results: Median TSH concentrations were 1, 1.10, and 2.76 mU/l for the Belgian, Norwegian, and Slovak cohorts, respectively. For polychlorinated biphenyl (PCB)-153 and dichlorodiphenyldichloroethylene (p,p′-DDE), children in the third exposure quartile had a 12-15% lower TSH at birth. Results remained unchanged after additional adjustment for birth weight and gestational weight gain. No effect on TSH was observed for the other compounds.Conclusion: Early life exposure to PCB-153 and p,p′-DDE impacts newborn TSH levels. Higher exposure levels were associated with 12-15% lower TSH levels.

U2 - 10.1038/pr.2017.50

DO - 10.1038/pr.2017.50

M3 - Article

C2 - 28288144

AN - SCOPUS:85028333313

SN - 0031-3998

VL - 82

SP - 429

EP - 437

JO - Pediatric Research

JF - Pediatric Research

IS - 3

ER -

Thyroid-stimulating hormone levels in newborns and early life exposure to endocrine-disrupting chemicals: Analysis of three European mother-child cohorts

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