Time course of action and intubating conditions following vecuronium, rocuronium and mivacurium

JMKH WIERDA*, FDM HOMMES, HJA NAP, L VANDENBROEK

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    42 Citations (Scopus)

    Abstract

    The purpose of this study was to compare the time course of action and tracheal intubating conditions of vecuronium, rocuronium, and mivacurium in anaesthetised patients. Anaesthesia consisted of thiopentone, fentanyl, N2O/O-2 and isoflurane. After a 2 x ED(50) dose the first attempt at tracheal intubation was made at 90 s. If required, maintenance doses of 0.5 x ED(50) were administered. The intubating conditions after rocuronium were significant better than those after vecuronium and mivacurium. The average onset times of rocuronium (172 s) and vecuronium (192 s) were significantly shorter than that mivacurium (229 s). The clinical duration and recovery time were significantly shorter after mivacurium (13 and 6 min, respectively) than with vecuronium (33 and 14 min, respectivelys) and rocuronium (28 and 11 min, respectively). We conclude that rocuronium might be of advantage whenever the interval between the administration of the muscle relaxant and tracheal intubation must be short, whereas mivacurium may be of benefit if fast spontaneous recovery is required.

    Original languageEnglish
    Pages (from-to)393-396
    Number of pages4
    JournalAnaesthesia
    Volume50
    Issue number5
    DOIs
    Publication statusPublished - May-1995

    Keywords

    • NEUROMUSCULAR RELAXANTS, VECURONIUM, ROCURONIUM, MIVACURIUM
    • NEUROMUSCULAR BLOCKING ACTION
    • NITROUS-OXIDE ANESTHESIA
    • ENFLURANE ANESTHESIA
    • MUSCLE-RELAXANTS
    • CHLORIDE
    • ORG-9426
    • SUCCINYLCHOLINE
    • SUXAMETHONIUM
    • INFUSION

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