Time course of arterial vascular adaptations to inactivity and paralyses in humans

Patricia C. E. De Groot; Dirk H. J. M. Van Kuppevelt; Cees Pons; Govert Snoek; Luc H. V. Van Der Woude; Maria T. E. Hopman

doi:10.1249/01.MSS.0000099088.21547.67

Time course of arterial vascular adaptations to inactivity and paralyses in humans

Patricia C. E. De Groot
, Dirk H. J. M. Van Kuppevelt
, Cees Pons
, Govert Snoek
, Luc H. V. Van Der Woude
, Maria T. E. Hopman

Research output: Contribution to journal › Article › Academic › peer-review

68 Citations (Scopus)

Abstract

PURPOSE: The aim of the present study was to assess the time course of vascular adaptations to inactivity and paralyses in humans. The spinal cord-injured (SCI) population offers a unique "human model of nature" to assess peripheral vascular adaptations and its time course to extreme inactivity and paralyses.

METHODS: Arterial diameters and red blood cell velocity of the carotid artery (CA), common femoral artery (FA), and brachial artery (BA) were measured using echo Doppler ultrasound. Fifteen SCI persons with lesions varying from 6 wk to 13 months postinjury participated in a cross-sectional study (SCI-CS), 6 SCI individuals were included for longitudinal measurements (SCI-L) at weeks 6, 8, 12, 16, 20, and 24 after the trauma, and 16 able-bodied individuals served as a control group (C).

RESULTS: Within 6 wk after the SCI, diameter (SCI-CS: 0.68 +/- 0.09 cm, SCI-L: 0.67 +/- 0.04 cm, C: 0.95 +/- 0.07 cm) and blood flow (SCI-CS: 299 +/- 112 mL x min(-1), SCI-L 279: +/- 52 mL x min(-1), C: 405 +/- 97 mL x min(-1)) of the femoral artery were significantly reduced (P < 0.001), and local femoral wall shear rate was almost doubled in SCI-CS and SC-L compared with C (P < 0.001). No further changes in femoral arterial properties were observed between week 6 and 13 months postinjury in SCI-L as well as SCI-CS. Carotid and brachial artery diameter and flow were similar in SCI and C and did not change between 6 wk and 13 months after the injury.

CONCLUSION: We conclude that the process of vascular adaptations to inactivity and paralyses in humans seems to be largely completed within weeks.

Original language	English
Pages (from-to)	1977-1985
Number of pages	9
Journal	Medicine and Science in Sports and Exercise
Volume	35
Issue number	12
DOIs	https://doi.org/10.1249/01.MSS.0000099088.21547.67
Publication status	Published - Dec-2003
Externally published	Yes

Keywords

Adaptation, Physiological
Arteries
Cross-Sectional Studies
Erythrocytes
Female
Hemodynamics
Humans
Male
Paralysis
Physical Fitness
Prospective Studies
Spinal Cord Injuries
Time Factors

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@article{b2ba77c81e1f49d7a780b968b6e93791,

title = "Time course of arterial vascular adaptations to inactivity and paralyses in humans",

abstract = "PURPOSE: The aim of the present study was to assess the time course of vascular adaptations to inactivity and paralyses in humans. The spinal cord-injured (SCI) population offers a unique {"}human model of nature{"} to assess peripheral vascular adaptations and its time course to extreme inactivity and paralyses.METHODS: Arterial diameters and red blood cell velocity of the carotid artery (CA), common femoral artery (FA), and brachial artery (BA) were measured using echo Doppler ultrasound. Fifteen SCI persons with lesions varying from 6 wk to 13 months postinjury participated in a cross-sectional study (SCI-CS), 6 SCI individuals were included for longitudinal measurements (SCI-L) at weeks 6, 8, 12, 16, 20, and 24 after the trauma, and 16 able-bodied individuals served as a control group (C).RESULTS: Within 6 wk after the SCI, diameter (SCI-CS: 0.68 +/- 0.09 cm, SCI-L: 0.67 +/- 0.04 cm, C: 0.95 +/- 0.07 cm) and blood flow (SCI-CS: 299 +/- 112 mL x min(-1), SCI-L 279: +/- 52 mL x min(-1), C: 405 +/- 97 mL x min(-1)) of the femoral artery were significantly reduced (P < 0.001), and local femoral wall shear rate was almost doubled in SCI-CS and SC-L compared with C (P < 0.001). No further changes in femoral arterial properties were observed between week 6 and 13 months postinjury in SCI-L as well as SCI-CS. Carotid and brachial artery diameter and flow were similar in SCI and C and did not change between 6 wk and 13 months after the injury.CONCLUSION: We conclude that the process of vascular adaptations to inactivity and paralyses in humans seems to be largely completed within weeks.",

keywords = "Adaptation, Physiological, Arteries, Cross-Sectional Studies, Erythrocytes, Female, Hemodynamics, Humans, Male, Paralysis, Physical Fitness, Prospective Studies, Spinal Cord Injuries, Time Factors",

author = "\{De Groot\}, \{Patricia C. E.\} and \{Van Kuppevelt\}, \{Dirk H. J. M.\} and Cees Pons and Govert Snoek and \{Van Der Woude\}, \{Luc H. V.\} and Hopman, \{Maria T. E.\}",

year = "2003",

month = dec,

doi = "10.1249/01.MSS.0000099088.21547.67",

language = "English",

volume = "35",

pages = "1977--1985",

journal = "Medicine and Science in Sports and Exercise",

issn = "0195-9131",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

TY - JOUR

T1 - Time course of arterial vascular adaptations to inactivity and paralyses in humans

AU - De Groot, Patricia C. E.

AU - Van Kuppevelt, Dirk H. J. M.

AU - Pons, Cees

AU - Snoek, Govert

AU - Van Der Woude, Luc H. V.

AU - Hopman, Maria T. E.

PY - 2003/12

Y1 - 2003/12

N2 - PURPOSE: The aim of the present study was to assess the time course of vascular adaptations to inactivity and paralyses in humans. The spinal cord-injured (SCI) population offers a unique "human model of nature" to assess peripheral vascular adaptations and its time course to extreme inactivity and paralyses.METHODS: Arterial diameters and red blood cell velocity of the carotid artery (CA), common femoral artery (FA), and brachial artery (BA) were measured using echo Doppler ultrasound. Fifteen SCI persons with lesions varying from 6 wk to 13 months postinjury participated in a cross-sectional study (SCI-CS), 6 SCI individuals were included for longitudinal measurements (SCI-L) at weeks 6, 8, 12, 16, 20, and 24 after the trauma, and 16 able-bodied individuals served as a control group (C).RESULTS: Within 6 wk after the SCI, diameter (SCI-CS: 0.68 +/- 0.09 cm, SCI-L: 0.67 +/- 0.04 cm, C: 0.95 +/- 0.07 cm) and blood flow (SCI-CS: 299 +/- 112 mL x min(-1), SCI-L 279: +/- 52 mL x min(-1), C: 405 +/- 97 mL x min(-1)) of the femoral artery were significantly reduced (P < 0.001), and local femoral wall shear rate was almost doubled in SCI-CS and SC-L compared with C (P < 0.001). No further changes in femoral arterial properties were observed between week 6 and 13 months postinjury in SCI-L as well as SCI-CS. Carotid and brachial artery diameter and flow were similar in SCI and C and did not change between 6 wk and 13 months after the injury.CONCLUSION: We conclude that the process of vascular adaptations to inactivity and paralyses in humans seems to be largely completed within weeks.

AB - PURPOSE: The aim of the present study was to assess the time course of vascular adaptations to inactivity and paralyses in humans. The spinal cord-injured (SCI) population offers a unique "human model of nature" to assess peripheral vascular adaptations and its time course to extreme inactivity and paralyses.METHODS: Arterial diameters and red blood cell velocity of the carotid artery (CA), common femoral artery (FA), and brachial artery (BA) were measured using echo Doppler ultrasound. Fifteen SCI persons with lesions varying from 6 wk to 13 months postinjury participated in a cross-sectional study (SCI-CS), 6 SCI individuals were included for longitudinal measurements (SCI-L) at weeks 6, 8, 12, 16, 20, and 24 after the trauma, and 16 able-bodied individuals served as a control group (C).RESULTS: Within 6 wk after the SCI, diameter (SCI-CS: 0.68 +/- 0.09 cm, SCI-L: 0.67 +/- 0.04 cm, C: 0.95 +/- 0.07 cm) and blood flow (SCI-CS: 299 +/- 112 mL x min(-1), SCI-L 279: +/- 52 mL x min(-1), C: 405 +/- 97 mL x min(-1)) of the femoral artery were significantly reduced (P < 0.001), and local femoral wall shear rate was almost doubled in SCI-CS and SC-L compared with C (P < 0.001). No further changes in femoral arterial properties were observed between week 6 and 13 months postinjury in SCI-L as well as SCI-CS. Carotid and brachial artery diameter and flow were similar in SCI and C and did not change between 6 wk and 13 months after the injury.CONCLUSION: We conclude that the process of vascular adaptations to inactivity and paralyses in humans seems to be largely completed within weeks.

KW - Adaptation, Physiological

KW - Arteries

KW - Cross-Sectional Studies

KW - Erythrocytes

KW - Female

KW - Hemodynamics

KW - Humans

KW - Male

KW - Paralysis

KW - Physical Fitness

KW - Prospective Studies

KW - Spinal Cord Injuries

KW - Time Factors

U2 - 10.1249/01.MSS.0000099088.21547.67

DO - 10.1249/01.MSS.0000099088.21547.67

M3 - Article

C2 - 14652491

SN - 0195-9131

VL - 35

SP - 1977

EP - 1985

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

IS - 12

ER -

Time course of arterial vascular adaptations to inactivity and paralyses in humans

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