Time to positivity of acute and chronic periprosthetic joint infection cultures

D T Talsma, J J W Ploegmakers, P C Jutte, G Kampinga, M Wouthuyzen-Bakker*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)
224 Downloads (Pure)

Abstract

Introduction: A prolonged incubation time is generally recommended for diagnosing periprosthetic joint infections (PJI). However, in literature, no distinction is made between acute and chronic infections.

Methods: All patients with a PJI that underwent surgical debridement between November 2015 and February 2019 with or without revision of the prosthesis were retrospectively evaluated. Synovial fluid, 5 intraoperative periprosthetic tissue samples, and the sonicated prosthesis were cultured.

Results: Fifty-nine patients were analyzed, including 21 acute PJIs (33 isolates) and 38 chronic PJIs (46 isolates). In acute PJIs, all isolates grew within 5 days, while this took 11 days for chronic PJIs. Sonication fluid showed the shortest time to positivity (78% at day 2) for chronic PJIs, but no difference was observed for acute PJIs compared to tissue cultures.

Conclusion: In contrast to cultures from chronic PJIs, acute PJIs do not need a prolonged incubation time and no clear benefit is observed for sonication. (C) 2020 The Authors. Published by Elsevier Inc.

Original languageEnglish
Article number115178
Number of pages6
JournalDiagnostic microbiology and infectious disease
Volume99
Issue number1
Early online date14-Aug-2020
DOIs
Publication statusPublished - Jan-2021

Keywords

  • Periprosthetic joint infection
  • Diagnosis
  • Acute
  • Chronic
  • Time to positivity
  • Sonication
  • PROPIONIBACTERIUM-ACNES
  • DIAGNOSIS
  • BIOFILMS

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