Tissue reactions to bacteria-inoculated rat lead samples .1. Effect of local gentamicin release through vicinal sponge or solution-dipping

PB vanWachem*, MJA vanLuyn, AW deWit, D Raatjes, M Hendriks, MLPM Verhoeven, PT Cahalan

*Corresponding author for this work

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The effect of local gentamicin release through a vicinal collagen sponge or through preoperative solution-dipping of rat lead samples was investigated in an early-infection model. The efficacy of these methods and their effect on tissue response were determined. It was demonstrated that both methods of local gentamicin release suppress lead-related infectious complications as compared to the control lead, which showed a high presence of inflamed/infected tissues and bacterial growth at each explantation time point. The first day the vicinal collagen sponge was more effective in suppressing the infection than was the solution-dipped lead, probably because there is a faster and higher dose release of gentamicin from the sponge. However, continued implantation time revealed that gentamicin release from the solution-dipped lead was more effective than the sponge. This supports our hypothesis that the presence of lumina are decisive for bacterial growth and persistence of implant-related infections. (C) 1997 John Wiley & Sons, Inc.

Original languageEnglish
Pages (from-to)217-232
Number of pages16
JournalJournal of Biomedical Materials Research
Issue number2
Publication statusPublished - May-1997


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