TNF family ligand variants

Wilhelmus Johannes Quax; Vicente R Tur; Luis Serrano; Albert Martinus van der Sloot; Robbert H. Cool; Aart H. G.  van Assen

TNF family ligand variants

Wilhelmus Johannes Quax (Inventor)
, Vicente R Tur (Inventor)
, Luis Serrano (Inventor)
, Albert Martinus van der Sloot (Inventor)
, Robbert H. Cool (Inventor)
, Aart H. G. van Assen (Inventor)

Research output: Patent

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Abstract

The present invention relates to variants of TNF family ligands which have been mutated at the ligand trimerisation interface so that they are not capable of assembling into trimers, and either assemble into dimers or remain as monomers. Such ligands bind to the TNF receptor but are unable to activate it, effectively functioning as competitive inhibitors. The invention also relates to nucleic acids encoding the variants of TNF family ligands, vectors and host cells comprising the nucleic acid and methods for the treatment of diseases associated with aberrant signalling through a TNF receptor.

Original language	English
Patent number	WO2012085891
Priority date	24/12/2010
Filing date	23/12/2011
Publication status	Published - 28-Jun-2012

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title = "TNF family ligand variants",

abstract = "The present invention relates to variants of TNF family ligands which have been mutated at the ligand trimerisation interface so that they are not capable of assembling into trimers, and either assemble into dimers or remain as monomers. Such ligands bind to the TNF receptor but are unable to activate it, effectively functioning as competitive inhibitors. The invention also relates to nucleic acids encoding the variants of TNF family ligands, vectors and host cells comprising the nucleic acid and methods for the treatment of diseases associated with aberrant signalling through a TNF receptor.",

author = "Quax, \{Wilhelmus Johannes\} and Tur, \{Vicente R\} and Luis Serrano and \{van der Sloot\}, \{Albert Martinus\} and Cool, \{Robbert H.\} and \{van Assen\}, \{Aart H. G.\}",

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day = "28",

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T1 - TNF family ligand variants

AU - Quax, Wilhelmus Johannes

AU - Tur, Vicente R

AU - Serrano, Luis

AU - van der Sloot, Albert Martinus

AU - Cool, Robbert H.

AU - van Assen, Aart H. G.

PY - 2012/6/28

Y1 - 2012/6/28

N2 - The present invention relates to variants of TNF family ligands which have been mutated at the ligand trimerisation interface so that they are not capable of assembling into trimers, and either assemble into dimers or remain as monomers. Such ligands bind to the TNF receptor but are unable to activate it, effectively functioning as competitive inhibitors. The invention also relates to nucleic acids encoding the variants of TNF family ligands, vectors and host cells comprising the nucleic acid and methods for the treatment of diseases associated with aberrant signalling through a TNF receptor.

AB - The present invention relates to variants of TNF family ligands which have been mutated at the ligand trimerisation interface so that they are not capable of assembling into trimers, and either assemble into dimers or remain as monomers. Such ligands bind to the TNF receptor but are unable to activate it, effectively functioning as competitive inhibitors. The invention also relates to nucleic acids encoding the variants of TNF family ligands, vectors and host cells comprising the nucleic acid and methods for the treatment of diseases associated with aberrant signalling through a TNF receptor.

M3 - Patent

M1 - WO2012085891

Y2 - 2011/12/23

ER -

TNF family ligand variants

Abstract

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