Tobacco and alcohol use during pregnancy and risk of oral clefts

C Lorente; S Cordier; J Goujard; S Ayme; E Calzolari; HEK De Walle; R Knill-Jones; Occupational Exposure & Congenital

Tobacco and alcohol use during pregnancy and risk of oral clefts

C Lorente^*, S Cordier, J Goujard, S Ayme, E Calzolari, HEK De Walle, R Knill-Jones, Occupational Exposure & Congenital

^*Corresponding author for this work

Reproductive Origins of Adult Health and Disease (ROAHD)

Research output: Contribution to journal › Article › Academic › peer-review

124 Citations (Scopus)

Abstract

Objectives. This study examined the relationship between maternal tobacco and alcohol consumption during the first trimester of pregnancy and oral clefts.

Methods. Data were derived from a European multicenter case-control study including 161 infants with oral clefts and 1134 control infants.

Results. Multivariate analyses showed an increased risk of cleft lip with or without cleft palate associated with smoking (odds ratio [OR]= 1.79, 95% confidence interval [CI]= 1.07, 3.04) and an increased risk of cleft palate associated with alcohol consumption (OR = 2.28, 95% CI = 1.02, 5.09). The former risk increased with the number of cigarettes smoked.

Conclusions. This study provides further evidence of the possible role of prevalent environmental exposures such as tobacco and alcohol in the etiology of oral clefts.

Original language	English
Pages (from-to)	415-419
Number of pages	5
Journal	AMERICAN JOURNAL OF PUBLIC HEALTH
Volume	90
Issue number	3
Publication status	Published - Mar-2000

Keywords

MATERNAL CIGARETTE-SMOKING
CONGENITAL-MALFORMATIONS
BIRTH-DEFECTS
OROFACIAL CLEFTS
POPULATION
PALATE
LIP
EXPOSURE

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@article{a6ae406004234d37986b4bac92dd894a,

title = "Tobacco and alcohol use during pregnancy and risk of oral clefts",

abstract = "Objectives. This study examined the relationship between maternal tobacco and alcohol consumption during the first trimester of pregnancy and oral clefts.Methods. Data were derived from a European multicenter case-control study including 161 infants with oral clefts and 1134 control infants.Results. Multivariate analyses showed an increased risk of cleft lip with or without cleft palate associated with smoking (odds ratio [OR]= 1.79, 95% confidence interval [CI]= 1.07, 3.04) and an increased risk of cleft palate associated with alcohol consumption (OR = 2.28, 95% CI = 1.02, 5.09). The former risk increased with the number of cigarettes smoked.Conclusions. This study provides further evidence of the possible role of prevalent environmental exposures such as tobacco and alcohol in the etiology of oral clefts.",

keywords = "MATERNAL CIGARETTE-SMOKING, CONGENITAL-MALFORMATIONS, BIRTH-DEFECTS, OROFACIAL CLEFTS, POPULATION, PALATE, LIP, EXPOSURE",

author = "C Lorente and S Cordier and J Goujard and S Ayme and E Calzolari and {De Walle}, HEK and R Knill-Jones and {Occupational Exposure & Congenital}",

year = "2000",

month = mar,

language = "English",

volume = "90",

pages = "415--419",

journal = "AMERICAN JOURNAL OF PUBLIC HEALTH",

issn = "0090-0036",

publisher = "AMER PUBLIC HEALTH ASSOC INC",

number = "3",

}

TY - JOUR

T1 - Tobacco and alcohol use during pregnancy and risk of oral clefts

AU - Lorente, C

AU - Cordier, S

AU - Goujard, J

AU - Ayme, S

AU - Calzolari, E

AU - De Walle, HEK

AU - Knill-Jones, R

AU - Occupational Exposure & Congenital

PY - 2000/3

Y1 - 2000/3

N2 - Objectives. This study examined the relationship between maternal tobacco and alcohol consumption during the first trimester of pregnancy and oral clefts.Methods. Data were derived from a European multicenter case-control study including 161 infants with oral clefts and 1134 control infants.Results. Multivariate analyses showed an increased risk of cleft lip with or without cleft palate associated with smoking (odds ratio [OR]= 1.79, 95% confidence interval [CI]= 1.07, 3.04) and an increased risk of cleft palate associated with alcohol consumption (OR = 2.28, 95% CI = 1.02, 5.09). The former risk increased with the number of cigarettes smoked.Conclusions. This study provides further evidence of the possible role of prevalent environmental exposures such as tobacco and alcohol in the etiology of oral clefts.

AB - Objectives. This study examined the relationship between maternal tobacco and alcohol consumption during the first trimester of pregnancy and oral clefts.Methods. Data were derived from a European multicenter case-control study including 161 infants with oral clefts and 1134 control infants.Results. Multivariate analyses showed an increased risk of cleft lip with or without cleft palate associated with smoking (odds ratio [OR]= 1.79, 95% confidence interval [CI]= 1.07, 3.04) and an increased risk of cleft palate associated with alcohol consumption (OR = 2.28, 95% CI = 1.02, 5.09). The former risk increased with the number of cigarettes smoked.Conclusions. This study provides further evidence of the possible role of prevalent environmental exposures such as tobacco and alcohol in the etiology of oral clefts.

KW - MATERNAL CIGARETTE-SMOKING

KW - CONGENITAL-MALFORMATIONS

KW - BIRTH-DEFECTS

KW - OROFACIAL CLEFTS

KW - POPULATION

KW - PALATE

KW - LIP

KW - EXPOSURE

M3 - Article

SN - 0090-0036

VL - 90

SP - 415

EP - 419

JO - AMERICAN JOURNAL OF PUBLIC HEALTH

JF - AMERICAN JOURNAL OF PUBLIC HEALTH

IS - 3

ER -

Tobacco and alcohol use during pregnancy and risk of oral clefts

Abstract

Keywords

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