Abstract
Background
It is generally unknown to what extent organ transplant recipients can be physically challenged. During an expedition to Mount Kilimanjaro, the tolerance for strenuous physical activity and high-altitude of organ transplant recipients after various types of transplantation was compared to non-transplanted controls.
Methods
Twelve organ transplant recipients were selected to participate (2 heart-, 2 lung-, 2 kidney-, 4 liver-, 1 allogeneic stem cell-and 1 small bowel-transplantation). Controls comprised the members of the medical team and accompanying family members (n = 14). During the climb, cardiopulmonary parameters and symptoms of acute mountain sickness were recorded twice daily. Capillary blood analyses were performed three times during the climb and once following return.
Results
Eleven of the transplant participants and all controls began the final ascent from 4700 meters and reached over 5000 meters. Eight transplant participants (73%) and thirteen controls (93%) reached the summit (5895m). Cardiopulmonary parameters and altitude sickness scores demonstrated no differences between transplant participants and controls. Signs of hyperventilation were more pronounced in transplant participants and adaptation to high-altitude was less effective, which was related to a decreased renal function. This resulted in reduced metabolic compensation.
Conclusion
Overall, tolerance to strenuous physical activity and feasibility of a high-altitude expedition in carefully selected organ transplant recipients is comparable to non-transplanted controls.
Original language | English |
---|---|
Article number | e0142641 |
Number of pages | 13 |
Journal | PLoS ONE |
Volume | 10 |
Issue number | 11 |
DOIs | |
Publication status | Published - 25-Nov-2015 |
Keywords
- HAND-HELD DYNAMOMETRY
- SUCCESS
- VALUES
Fingerprint
Dive into the research topics of 'Tolerance of Organ Transplant Recipients to Physical Activity during a High-Altitude Expedition: Climbing Mount Kilimanjaro'. Together they form a unique fingerprint.Datasets
-
TransplantLines
Bakker, S. (Creator), Leuvenink, H. G. D. (Creator) & Porte, R. J. (Creator), University of Groningen, 2017
http://www.transplantlines.umcg.nl
Dataset
-
Data for: Tolerance of Organ Transplant Recipients to Physical Activity during a High-Altitude Expedition: climbing Mount Kilimanjaro
van Adrichem, E. (Creator), Siebelink, M. (Creator), Rottier, B. (Creator), Dilling, J. M. (Creator), van der Schans, C. P. (Creator) & Verschuuren, E. A. M. (Creator), University of Groningen, 15-Oct-2015
Dataset