Toll-like receptors in the pathogenesis of human B cell malignancies

Johana M. Isaza-Correa, Zheng Liang, Anke van den Berg, Arjan Diepstra, Lydia Visser*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

31 Citations (Scopus)
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Abstract

Toll-like receptors (TLRs) are important players in B-cell activation, maturation and memory and may be involved in the pathogenesis of B-cell lymphomas. Accumulating studies show differential expression in this heterogeneous group of cancers. Stimulation with TLR specific ligands, or agonists of their ligands, leads to aberrant responses in the malignant B-cells. According to current data, TLRs can be implicated in malignant transformation, tumor progression and immune evasion processes. Most of the studies focused on multiple myeloma and chronic lymphocytic leukemia, but in the last decade the putative role of TLRs in other types of B-cell lymphomas has gained much interest. The aim of this review is to discuss recent findings on the role of TLRs in normal B cell functioning and their role in the pathogenesis of B-cell malignancies.

Original languageEnglish
Article number57
Number of pages10
JournalJournal of Hematology & Oncology
Volume7
Issue number1
DOIs
Publication statusPublished - 12-Aug-2014

Keywords

  • CHRONIC LYMPHOCYTIC-LEUKEMIA
  • ACUTE LYMPHOBLASTIC-LEUKEMIA
  • IMMUNOSTIMULATORY CPG-OLIGONUCLEOTIDES
  • NON-HODGKIN-LYMPHOMA
  • REGULATORY T-CELLS
  • HELICOBACTER-PYLORI
  • FOLLICULAR LYMPHOMA
  • MULTIPLE-MYELOMA
  • DENDRITIC CELLS
  • 1018 ISS

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