Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala

Y Kawahara*, M.B. Hesselink, G van Scharrenburg, B.H.C. Westerink

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Abstract

The present microdialysis study investigated whether nociceptin/orphanin FQ exerts a tonic inhibition of the release of noradrenaline in the basolateral nucleus of the amygdala in awake rats. The non-peptide competitive nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist J-113397 (20 mg/kg i.p.) induced an increase in the release of noradrenaline to about 150-200%. The increase was strongly suppressed by local infusion of an endogenous N/OFQ peptide receptor agonist, nociceptin/orphanin FQ (1 muM) via retrograde microdialysis, into the basolateral nucleus of the amygdala. Local infusion of nociceptin/orphanin FQ 1 muM) itself reduced noradrenaline release in the basolateral nucleus of the amygdala to about 70% of basal levels. These results indicate that a large part of basal release of noradrenaline in the basolateral nucleus of the amygdala is under tonic inhibitory control by endogenous nociceptin/orphanin FQ through the N/OFQ peptide receptors localized within the basolateral nucleus of the amygdala. (C) 2003 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalEuropean Journal of Pharmacology
Volume485
Issue number1-3
DOIs
Publication statusPublished - 6-Feb-2004

Keywords

  • J-113397
  • microdialysis
  • orphanin FQ
  • nociceptin
  • amygdala
  • (rat)
  • NOCICEPTIN/ORPHANIN FQ
  • RAT-BRAIN
  • RECEPTOR
  • RELEASE
  • MICRODIALYSIS
  • MEMORY
  • STRESS
  • ORL1
  • NOREPINEPHRINE
  • PROFILE

Cite this