Topography-mediated Control of Cellular Response: Migration, Intracellular Crowding, and Gene-delivery

Lu Ge

    Research output: ThesisThesis fully internal (DIV)

    528 Downloads (Pure)


    Overall, the work presented in this thesis is to explore topography-mediated alterations of cell behaviors and investigate cell-material interface-induced subcellular behaviors like cell morphology alteration, cell migration in wound healing, intracellular macromolecular crowding, and topography-modulated gene delivery of stem cells. The work demonstrates that the topography plays an important role in modulating cell behaviors, which provides useful information to better understanding material-cells interfaces and many new insights may be elucidated for tissue engineering and regenerative medicine approaches.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • University of Groningen
    • van Rijn, Patrick, Supervisor
    • van Kooten, Theo, Co-supervisor
    Award date7-Dec-2020
    Place of Publication[Groningen]
    Publication statusPublished - 2020

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