Topography-mediated Control of Cellular Response: Migration, Intracellular Crowding, and Gene-delivery

Lu Ge

doi:10.33612/diss.146106454

Topography-mediated Control of Cellular Response: Migration, Intracellular Crowding, and Gene-delivery

Lu Ge

Research output: Thesis › Thesis fully internal (DIV)

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Abstract

Overall, the work presented in this thesis is to explore topography-mediated alterations of cell behaviors and investigate cell-material interface-induced subcellular behaviors like cell morphology alteration, cell migration in wound healing, intracellular macromolecular crowding, and topography-modulated gene delivery of stem cells. The work demonstrates that the topography plays an important role in modulating cell behaviors, which provides useful information to better understanding material-cells interfaces and many new insights may be elucidated for tissue engineering and regenerative medicine approaches.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Groningen
Supervisors/Advisors	van Rijn, Patrick, Supervisor van Kooten, Theo, Co-supervisor
Award date	7-Dec-2020
Place of Publication	[Groningen]
Publisher	University of Groningen
DOIs	https://doi.org/10.33612/diss.146106454
Publication status	Published - 2020

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10.33612/diss.146106454

Title and contentsFinal publisher's version, 373 KB
Chapter 1Final publisher's version, 1.19 MB
Chapter 2Final publisher's version, 1.81 MB
Chapter 3Final publisher's version, 2.37 MB
Chapter 4Final publisher's version, 1.35 MB
Chapter 5Final publisher's version, 1.52 MB
Chapter 6Final publisher's version, 1.09 MB
SummaryFinal publisher's version, 182 KB
SamenvattingFinal publisher's version, 341 KB
Complete thesisFinal publisher's version, 8.21 MB
PropositionsFinal publisher's version, 106 KB

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title = "Topography-mediated Control of Cellular Response: Migration, Intracellular Crowding, and Gene-delivery",

abstract = "Overall, the work presented in this thesis is to explore topography-mediated alterations of cell behaviors and investigate cell-material interface-induced subcellular behaviors like cell morphology alteration, cell migration in wound healing, intracellular macromolecular crowding, and topography-modulated gene delivery of stem cells. The work demonstrates that the topography plays an important role in modulating cell behaviors, which provides useful information to better understanding material-cells interfaces and many new insights may be elucidated for tissue engineering and regenerative medicine approaches.",

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language = "English",

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AU - Ge, Lu

PY - 2020

Y1 - 2020

N2 - Overall, the work presented in this thesis is to explore topography-mediated alterations of cell behaviors and investigate cell-material interface-induced subcellular behaviors like cell morphology alteration, cell migration in wound healing, intracellular macromolecular crowding, and topography-modulated gene delivery of stem cells. The work demonstrates that the topography plays an important role in modulating cell behaviors, which provides useful information to better understanding material-cells interfaces and many new insights may be elucidated for tissue engineering and regenerative medicine approaches.

AB - Overall, the work presented in this thesis is to explore topography-mediated alterations of cell behaviors and investigate cell-material interface-induced subcellular behaviors like cell morphology alteration, cell migration in wound healing, intracellular macromolecular crowding, and topography-modulated gene delivery of stem cells. The work demonstrates that the topography plays an important role in modulating cell behaviors, which provides useful information to better understanding material-cells interfaces and many new insights may be elucidated for tissue engineering and regenerative medicine approaches.

U2 - 10.33612/diss.146106454

DO - 10.33612/diss.146106454

M3 - Thesis fully internal (DIV)

PB - University of Groningen

CY - [Groningen]

ER -

Topography-mediated Control of Cellular Response: Migration, Intracellular Crowding, and Gene-delivery

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