Toward Using Fluorescent Nanodiamonds To Study Chronological Aging in Saccharomyces cerevisiae

Kiran van der Laan, Julie Naulleau, Viraj G Damle, Alina Sigaeva, Nicolas Jamot, Felipe P Perona Martinez, Mayeul Chipaux, Romana Schirhagl*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

One of the theories aiming to explain cellular aging is the free radical theory of aging, which describes the possible role of increased production and accumulation of free radicals. Fluorescent nanodiamonds (FNDs) are proposed to provide a tool to detect these radicals, as they function as magnetic sensors that change their optical properties depending on their magnetic surrounding. Therefore, they could enable the study of aging at a molecular level and unravel the exact role of free radicals in this process. In this study, important steps toward this goal are made. FNDs are introduced in chronologically aging yeast cells. Furthermore, the behavior of FNDs in these aging cells is studied to demonstrate the potency of using FNDs in the search for causes of cellular aging.

Original languageEnglish
Pages (from-to)13506-13513
Number of pages8
JournalAnalytical Chemistry
Volume90
Issue number22
Early online date2018
DOIs
Publication statusPublished - 20-Nov-2018

Keywords

  • YEAST
  • TRACKING
  • MODEL

Cite this