Towards precision medicine: What are the stratification hypotheses to identify homogeneous inflammatory subgroups

M Ioannou*, M Foiselle, J Mallet, E L Stam, O Godin, C Dubertret, E Terro, I E C Sommer, B C M Haarman, M Leboyer, R A Schoevers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Downloads (Pure)

Abstract

Diverse lines of research testify a link, presumably causal, between immune dysregulation and the development, course and clinical outcome of psychiatric disorders. However, there is a large heterogeneity among the patients? individual immune profile and this heterogeneity prevents the development of precise diagnostic tools and the identification of therapeutic targets. The aim of this review was to delineate possible subgroups of patients on the basis of clinical dimensions, investigating whether they could lead to particular immune signatures and tailored treatments. We discuss six clinical entry points; genetic liability to immune dysregula-tion, childhood maltreatment, metabolic syndrome, cognitive dysfunction, negative symptoms and treatment resistance. We describe the associated immune signature and outline the effects of anti-inflammatory drugs so far. Finally, we discuss advantages of this approach, challenges and future research directions.

(c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

Original languageEnglish
Pages (from-to)108-121
Number of pages14
JournalEuropean Neuropsychopharmacology
Volume45
Early online date11-Nov-2020
DOIs
Publication statusPublished - Apr-2021

Keywords

  • Mood disorders
  • Psychotic disorders
  • Inflammation
  • Biomarkers
  • Precision medicine
  • C-REACTIVE PROTEIN
  • MAJOR DEPRESSIVE DISORDER
  • N-ACETYL CYSTEINE
  • ADD-ON THERAPY
  • BIPOLAR DISORDER
  • METABOLIC SYNDROME
  • CHILDHOOD MALTREATMENT
  • SCHIZOPHRENIA-PATIENTS
  • IMMUNE-SYSTEM
  • CARDIOVASCULAR RISK

Cite this