Towards stem-cell therapy in the endocrine pancreas

Shanti T. Gangaram-Panday*, Marijke M. Faas, Paul de Vos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)

Abstract

Many approaches of stem-cell therapy for the treatment of diabetes have been described. One is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell transplantation. During recent years three types of stem cells have been investigated: embryonic stem cells, bone-marrow-derived stem cells and organ-bound stem cells. We discuss the advantages and limitations of these different cell types. The applicability for the treatment of dysfunction of 0 cells in the pancreas has been demonstrated for all three cell types, but more-detailed understanding of the sequence of events during differentiation is required to produce fully functional insulin-producing cells.

Original languageEnglish
Pages (from-to)164-173
Number of pages10
JournalTRENDS IN MOLECULAR MEDICINE
Volume13
Issue number4
DOIs
Publication statusPublished - Apr-2007

Keywords

  • INSULIN-PRODUCING CELLS
  • UMBILICAL-CORD BLOOD
  • NESTIN-POSITIVE PROGENITOR
  • POSTNATAL RAT PANCREAS
  • BONE-MARROW
  • IN-VITRO
  • BETA-CELLS
  • EPITHELIAL MONOLAYERS
  • DIABETES-MELLITUS
  • ISLET-CELL

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