Abstract
Many approaches of stem-cell therapy for the treatment of diabetes have been described. One is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell transplantation. During recent years three types of stem cells have been investigated: embryonic stem cells, bone-marrow-derived stem cells and organ-bound stem cells. We discuss the advantages and limitations of these different cell types. The applicability for the treatment of dysfunction of 0 cells in the pancreas has been demonstrated for all three cell types, but more-detailed understanding of the sequence of events during differentiation is required to produce fully functional insulin-producing cells.
Original language | English |
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Pages (from-to) | 164-173 |
Number of pages | 10 |
Journal | TRENDS IN MOLECULAR MEDICINE |
Volume | 13 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr-2007 |
Keywords
- INSULIN-PRODUCING CELLS
- UMBILICAL-CORD BLOOD
- NESTIN-POSITIVE PROGENITOR
- POSTNATAL RAT PANCREAS
- BONE-MARROW
- IN-VITRO
- BETA-CELLS
- EPITHELIAL MONOLAYERS
- DIABETES-MELLITUS
- ISLET-CELL