Towards tailored vaccine delivery: Needs, challenges and perspectives

Jean-Pierre Amorij, Gideon F. A. Kersten, Vinay Saluja, Wouter F. Tonnis, Wouter L. J. Hinrichs, Bram Slutter, Suzanne M. Bal, Joke A. Bouwstra, Anke Huckriede, Wim Jiskoot*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

77 Citations (Scopus)

Abstract

The ideal vaccine is a simple and stable formulation which can be conveniently administered and provides life-long immunity against a given pathogen. The development of such a vaccine, which should trigger broad and strong B-cell and T-cell responses against antigens of the pathogen in question, is highly dependent on tailored vaccine delivery approaches. This review addresses vaccine delivery in its broadest scope. We discuss the needs and challenges in the area of vaccine delivery, including restrictions posed by specific target populations, potentials of dedicated stable formulations and devices, and the use of adjuvants. Moreover, we address the current status and perspectives of vaccine delivery via several routes of administration, including non-or minimally invasive routes. Finally we suggest possible directions for future vaccine delivery research and development. (C) 2012 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)363-376
Number of pages14
JournalJournal of Controlled Release
Volume161
Issue number2
DOIs
Publication statusPublished - 20-Jul-2012

Keywords

  • Adjuvant
  • Device
  • Formulation
  • Mucosal vaccination
  • Targeting
  • Transcutaneous vaccination
  • INFLUENZA SUBUNIT VACCINE
  • TOLL-LIKE RECEPTORS
  • T-CELL RESPONSES
  • RESPIRATORY SYNCYTIAL VIRUS
  • PLASMODIUM-FALCIPARUM MALARIA
  • IMMUNOLOGICAL ADJUVANT QS-21
  • RECOMBINANT PROTEIN VACCINE
  • MEDIATED IMMUNE-RESPONSES
  • HEAT-LABILE TOXIN
  • PHASE-I TRIAL

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