Toxicity of nanomaterials

Shahriar Sharifi, Shahed Behzadi, Sophie Laurent, M. Laird Forrest, Pieter Stroeve, Morteza Mahmoudi*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    857 Citations (Scopus)

    Abstract

    Nanoscience has matured significantly during the last decade as it has transitioned from bench top science to applied technology. Presently, nanomaterials are used in a wide variety of commercial products such as electronic components, sports equipment, sun creams and biomedical applications. There are few studies of the long-term consequences of nanoparticles on human health, but governmental agencies, including the United States National Institute for Occupational Safety and Health and Japan's Ministry of Health, have recently raised the question of whether seemingly innocuous materials such as carbon-based nanotubes should be treated with the same caution afforded known carcinogens such as asbestos. Since nanomaterials are increasing a part of everyday consumer products, manufacturing processes, and medical products, it is imperative that both workers and end-users be protected from inhalation of potentially toxic NPs. It also suggests that NPs may need to be sequestered into products so that the NPs are not released into the atmosphere during the product's life or during recycling. Further, non-inhalation routes of NP absorption, including dermal and medical injectables, must be studied in order to understand possible toxic effects. Fewer studies to date have addressed whether the body can eventually eliminate nanomaterials to prevent particle build-up in tissues or organs. This critical review discusses the biophysicochemical properties of various nanomaterials with emphasis on currently available toxicology data and methodologies for evaluating nanoparticle toxicity (286 references).

    Original languageEnglish
    Pages (from-to)2323-2343
    Number of pages21
    JournalChemical Society Reviews
    Volume41
    Issue number6
    DOIs
    Publication statusPublished - 2012

    Keywords

    • IRON-OXIDE NANOPARTICLES
    • WALLED CARBON NANOTUBES
    • QUANTUM-DOT NANOPARTICLES
    • IN-VIVO BIODISTRIBUTION
    • TITANIUM-DIOXIDE NANOPARTICLES
    • COLLOIDAL GOLD NANOPARTICLES
    • SIZE-DEPENDENT CYTOTOXICITY
    • OXIDATIVE STRESS
    • PARTICLE-SIZE
    • DRUG-DELIVERY

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