@article{603dc7aa565148bbb1ecf794caa73edd,
title = "Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation",
abstract = "We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 x 10(-11) to 5.0 x 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 x 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.",
keywords = "PULMONARY ARTERIAL-HYPERTENSION, CENTRIC ARRAY, RISK-FACTORS, CARDIOVASCULAR-DISEASE, VARIANTS, REGIONS, KIDNEY, TISSUE, METAANALYSIS, INDIVIDUALS",
author = "Norihiro Kato and Marie Loh and Fumihiko Takeuchi and Niek Verweij and Xu Wang and Weihua Zhang and Kelly, {Tanika N.} and Danish Saleheen and Benjamin Lehne and Leach, {Irene Mateo} and Drong, {Alexander W.} and James Abbott and Simone Wahl and Sian-Tsung Tan and Scott, {William R.} and Gianluca Campanella and Marc Chadeau-Hyam and Uzma Afzal and Ahluwalia, {Tarunveer S.} and Bonder, {Marc Jan} and Peng Chen and Abbas Dehghan and Edwards, {Todd L.} and Tonu Esko and Go, {Min Jin} and Harris, {Sarah E.} and Jaana Hartiala and Silva Kasela and Anuradhani Kasturiratne and Chiea-Chuen Khor and Kleber, {Marcus E.} and Huaixing Li and Mok, {Zuan Yu} and Masahiro Nakatochi and Sapari, {Nur Sabrina} and Richa Saxena and Stewart, {Alexandre F. R.} and Lisette Stolk and Yasuharu Tabara and Ying Wu and Gansevoort, {Ron T.} and Meena Kumari and Harold Snieder and {van Gilst}, {Wiek H.} and {van Veldhuisen}, {Dirk J.} and Asselbergs, {Folkert W.} and Lude Franke and Cisca Wijmenga and Wolffenbuttel, {Bruce H. W.} and {van der Harst}, Pim and {BIOS Consortium} and {CARDIo GRAMplusCD} and {Lifelines Cohort Study} and {InterAct Consortium}",
year = "2015",
month = nov,
doi = "10.1038/ng.3405",
language = "English",
volume = "47",
pages = "1282--1293.e2",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",
}