Translational control of gene expression and disease

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Abstract

In the past decade, translational control has been shown to be crucial in the regulation of gene expression. Research in this field has progressed rapidly, revealing new control mechanisms and adding constantly to the list of translationally regulated genes. There is accumulating evidence that translational control plays a primary role in cell-cycle progression and cell differentiation, as well as in the induction of specific cellular functions. Recently, the aetiologies of several human diseases have been linked with mutations in genes of the translational control machinery, highlighting the significance of this regulatory mechanism. In addition, deregulation of translation is associated with a wide range of cancers. Current research focuses on novel therapeutic strategies that target translational control, a promising concept in the treatment of human diseases.

Original languageEnglish
Pages (from-to)577-83
Number of pages7
JournalTrends in Molecular Medicine
Volume8
Issue number12
DOIs
Publication statusPublished - Dec-2002
Externally publishedYes

Keywords

  • Eukaryotic Initiation Factors
  • Fragile X Syndrome
  • Gene Expression Regulation
  • Humans
  • Hyperbilirubinemia, Hereditary
  • Neoplasms
  • Protein Biosynthesis
  • Regulatory Sequences, Ribonucleic Acid
  • Signal Transduction
  • Thrombocytosis

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