Translational Perspective on Epigenetics in Cardiovascular Disease

Pim van der Harst*, Leon J. de Windt, John C. Chambers

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)

Abstract

A plethora of environmental and behavioral factors interact, resulting in changes in gene expression and providing a basis for the development and progression of cardiovascular diseases. Heterogeneity in gene expression responses among cells and individuals involves epigenetic mechanisms. Advancing technology allowing genome-scale interrogation of epigenetic marks provides a rapidly expanding view of the complexity and diversity of the epigenome. In this review, the authors discuss the expanding landscape of epigenetic modifications and highlight their importance for future understanding of disease. The epigenome provides a mechanistic link between environmental exposures and gene expression profiles ultimately leading to disease. The authors discuss the current evidence for transgenerational epigenetic inheritance and summarize the data linking epigenetics to cardiovascular disease. Furthermore, the potential targets provided by the epigenome for the development of future diagnostics, preventive strategies, and therapy for cardiovascular disease are reviewed. Finally, the authors provide some suggestions for future directions. (C) 2017 by the American College of Cardiology Foundation.

Original languageEnglish
Pages (from-to)590-606
Number of pages17
JournalJournal of the American College of Cardiology
Volume70
Issue number5
DOIs
Publication statusPublished - 1-Aug-2017

Keywords

  • EWAS
  • HAT
  • HDAC
  • histones
  • methylation
  • RNA
  • EPIGENOME-WIDE ASSOCIATION
  • SELECTIVE HDAC INHIBITORS
  • LONG NONCODING RNA
  • BODY-MASS INDEX
  • DNA METHYLATION
  • HISTONE DEACETYLASE
  • HEART-FAILURE
  • CARDIAC-HYPERTROPHY
  • CARDIOMYOCYTE HYPERTROPHY
  • INTRAUTERINE ENVIRONMENT

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