Translational research in pharmacology and toxicology using precision-cut tissue slices

Geny Groothuis, Angela Casini, Herman Meurs, Peter Olinga

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

2 Citations (Scopus)


In this chapter we discuss the application of human liver, intestine, lung and tumour precision-cut tissue slices (PCTS) as a translational ex vivo model in studies on ADME (absorption, distribution, metabolism and excretion) and toxicology of drugs, and for studies on diseases such as fibrosis in the liver and the intestine, obstructive lung diseases, viral infections and cancer. As the use of PCTS in research is steadily increasing it is impossible to give a fully comprehensive review of all applications of PCTS, but by highlighting some of the most important examples with a special emphasis on the application of human PCTS, we aim to show the extensive potential of this versatile technique in pathology and drug research.
Original languageEnglish
Title of host publicationHuman-based Systems for Translational Research
EditorsR. Coleman
Place of PublicationCambridge
PublisherRSC publishing
Number of pages27
ISBN (Electronic)978-1-78262-013-6
ISBN (Print)978-1-84973-825-5
Publication statusPublished - 2015

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