Translational research into sexual disorders: Pharmacology and genomics

Johnny S. W. Chan*, Berend Olivier, Trynke R. de Jong, Eelke M. S. Snoeren, Elke Kooijman, Felisa N. van Hasselt, Jules H. W. Limpens, Martien Kas, Marcel D. Waldinger, Ronald S. Oosting

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

The existence of sexual dysfunctions in men, including premature and retarded ejaculation poses challenges to develop translational models in rats that may help in improving treatment and delineate the neural mechanisms of action. Most of our current understanding of the neurobiology, neuroanatomy and psychopharmacology of sexual behavior and ejaculatory function has been derived from preclinical studies in the rat. When large populations of male rats are tested on sexual activity during four successive tests, over time individual rats display a very stable sexual behavior that is either slow, normal or fast as characterized by the number of ejaculations performed. These sexual endophenotypes are postulated as rat counterparts of premature (fast rats) or retarded ejaculation (slow rats). Psychopharmacology in these endophenotypes may help to delineate the underlying mechanisms and pathology. This is illustrated by the effects of serotonergic antidepressants and serotonergic compounds on sexual and ejaculatory behavior of rats. Further unravelling of sexual endophenotypes may benefit from the use of chromosomal substitution strains in mice that enable the localization of relevant chromosomal areas and genes involved in ejaculation processes. These preclinical studies and models contribute to a better understanding of the neurobiology of ejaculation and boost the development of novel drug targets to treat ejaculatory disorders such as premature and retarded ejaculation. (C) 2008 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)426-435
Number of pages10
JournalEuropean Journal of Pharmacology
Volume585
Issue number2-3
DOIs
Publication statusPublished - 13-May-2008
Externally publishedYes

Keywords

  • premature ejaculation
  • animal model
  • SSRI
  • dapoxetine
  • serotonin
  • endophenotype
  • RAT EJACULATORY BEHAVIOR
  • SEROTONIN REUPTAKE INHIBITORS
  • LIFELONG PREMATURE EJACULATION
  • DOI-INDUCED INHIBITION
  • COPULATORY-BEHAVIOR
  • DOUBLE-BLIND
  • DRUG-TREATMENT
  • CHRONIC FLUOXETINE
  • 5-HT1A RECEPTORS
  • SPINAL-CORD

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